Reactome | ALPK1:ADP heptose [cytosol]

ALPK1:ADP heptose [cytosol]

Stable Identifier

R-RNO-9645521

Type

Complex

Species

Rattus norvegicus

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-1 family signaling (Rattus norvegicus)
      - Interleukin-1 signaling (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Alpha-protein kinase 1 signaling pathway (Rattus norvegicus)
    - ALPK1 binds ADP-heptose (Rattus norvegicus)
      - ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - ALPK1 phosphorylates TIFA (Rattus norvegicus)
      - ALPK1:ADP-heptose:TIFA dimer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)
      - ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:TIFA dimer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - TIFA oligomerization (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
        
        Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Rattus norvegicus)
        
        ALPK1:ADP heptose [cytosol] (Rattus norvegicus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an input of

ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)

as an output of

ALPK1 binds ADP-heptose (Rattus norvegicus)

as a component of

Inferred From

ALPK1:ADP heptose [cytosol] (Homo sapiens)

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