Reactome | Upf2 [cytosol]

Upf2 [cytosol]

Stable Identifier

R-RNO-927799

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

UPF2, A0A0U1RRY8

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Upf2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0U1RRY8

Gene Names

Upf2

Reference Genes

BioGPS Gene:361271 Upf2

ENSEMBL:ENSRNOG00000023593

Monarch:361271 Upf2

NCBI Gene:361271 Upf2

UCSC:A0A0U1RRY8 Upf2

Reference Transcript

Other Identifiers

10799532

1389375_at

17720752

361271

5745009

5979706

6015322

6127369

6411315

6482461

6605654

A_42_P586681

A_44_P288997

A_64_P108544

GE1259183

GO:0000184

GO:0001889

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0031100

GO:0035145

GO:0036464

GO:0042162

GO:0043226

GO:0048471

GO:0048856

ILMN_1353804

PH_rn_0007886

PH_rn_0019136

Participates

as a component of

Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)

Inferred From

UPF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_063132701.1, XP_038951854.1, XP_038951852.1, XP_038951851.1, XP_063132703.1, XP_063132702.1

ENSEMBL

ENSRNOG00000023593, ENSRNOP00000075866, ENSRNOT00000092452

RGD

1309178