Reactome | IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

Stable Identifier

R-RNO-8987132

Type

Reaction [binding]

Species

Rattus norvegicus

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

PTPN11 binds to IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 activated receptor complex, PTPN11 binds to IL22 receptor complex, Shp2 is recruited to the tyrosine phosphorylated IL-22R1

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IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

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