Reactome | Commd2 [cytosol]

Commd2 [cytosol]

Stable Identifier

R-RNO-8955112

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

COMMD2, D3ZLN7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - 26S proteasome degrades HIFalpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZLN7

Gene Names

Commd2

Reference Genes

BioGPS Gene:688478 Commd2

ENSEMBL:ENSRNOG00000043386

KEGG:rno:688478 Commd2

Monarch:688478 Commd2

NCBI Gene:688478 Commd2

UCSC:D3ZLN7 Commd2

Reference Transcript

RefSeq:NM_001109503.1 Commd2

Other Identifiers

1372148_at

1382668_at

17747513

5658980

5777238

5833100

5900042

6137654

6157935

6313840

6498662

6531208

6577890

688478

A_43_P17256

A_64_P124928

A_64_P124933

GE1196876

ILMN_1650000

PH_rn_0008857

rc_AI169155_at

rc_AI232529_at

Participates

as a candidate of

COMMDs [cytosol] (Rattus norvegicus)

Other forms of this molecule

Commd2 [nucleoplasm]

Inferred From

COMMD2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001102973.1

ENSEMBL

ENSRNOT00000022778, ENSRNOP00000022778, ENSRNOG00000043386

RGD

1588810

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