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Cul3 [cytosol]
Stable Identifier
R-RNO-8952516
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
G76-NEDD8-K712-CUL3, B5DF89
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
MAP1LC3B binds KEAP1 and SQSTM1 (Rattus norvegicus)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
RBX1:CUL3 dissociates from forming autophagosome (Rattus norvegicus)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B5DF89
Gene Names
Cul3
Reference Genes
BioGPS Gene:301555 Cul3
ENSEMBL:ENSRNOG00000015633
ENSEMBL:ENSRNOG00055006821
ENSEMBL:ENSRNOG00060007351
ENSEMBL:ENSRNOG00065018395
KEGG:rno:301555 Cul3
Monarch:301555 Cul3
NCBI Gene:301555 Cul3
UCSC:B5DF89 Cul3
Reference Transcript
RefSeq:NM_001106923.2 Cul3
Other Identifiers
10929301
1393343_at
1396400_at
1399132_at
17865878
301555
5660342
5696317
5719056
5730856
5793945
5827208
5972415
6025570
6117324
6262077
6291272
6351634
6363648
6395484
6455571
6472991
6496280
6534760
6554473
6557917
6643167
6651446
6679590
A_42_P836526
A_43_P21143
A_44_P312103
A_44_P577351
GE1214621
GE1215066
GE1280694
GE15785
GO:0000122
GO:0000209
GO:0000278
GO:0000902
GO:0000922
GO:0001701
GO:0001831
GO:0003014
GO:0003824
GO:0004842
GO:0005112
GO:0005634
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005827
GO:0005886
GO:0005929
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006368
GO:0006511
GO:0006513
GO:0006515
GO:0006888
GO:0006915
GO:0006950
GO:0006954
GO:0006979
GO:0007080
GO:0007165
GO:0007229
GO:0007369
GO:0010467
GO:0010468
GO:0010558
GO:0016055
GO:0016192
GO:0016477
GO:0016567
GO:0016740
GO:0017145
GO:0030030
GO:0030163
GO:0030332
GO:0031145
GO:0031208
GO:0031398
GO:0031461
GO:0031463
GO:0031514
GO:0031625
GO:0031648
GO:0031669
GO:0032467
GO:0032480
GO:0032481
GO:0032869
GO:0034198
GO:0034599
GO:0035024
GO:0036126
GO:0040016
GO:0042802
GO:0043149
GO:0043161
GO:0043226
GO:0044346
GO:0045842
GO:0048208
GO:0048856
GO:0048870
GO:0051301
GO:0051865
GO:0060090
GO:0060337
GO:0061630
GO:0065003
GO:0070294
GO:0070936
GO:0071230
GO:0071630
GO:0072576
GO:0072686
GO:0080090
GO:0098794
GO:0098978
GO:0140096
GO:0140252
GO:0160072
GO:0160240
GO:1900076
GO:1901992
GO:1904262
GO:1904263
PH_rn_0006036
rc_AA901222_at
rc_AI072520_at
Participates
as a component of
NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Other forms of this molecule
Cul3 [nucleoplasm]
Cul3 [cytosol]
Inferred From
G76-NEDD8-K712-CUL3 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 712 (in Homo sapiens)
Coordinate
712
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
NP_001100393.2
ENSEMBL
ENSRNOP00000086948
,
ENSRNOT00000097044
,
ENSRNOG00000015633
PRO
B5DF89
RGD
1308190
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