Reactome | Lrig1 [plasma membrane]

Lrig1 [plasma membrane]

Stable Identifier

R-RNO-8875434

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Ub-LRIG1, M0RB60

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by MET (Rattus norvegicus)
    - Negative regulation of MET activity (Rattus norvegicus)
      - EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Rattus norvegicus)
        
        MET:Ub-LRIG1 [plasma membrane] (Rattus norvegicus)
        
        Lrig1 [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Rattus norvegicus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Rattus norvegicus)
        
        MET:Ub-LRIG1 [plasma membrane] (Rattus norvegicus)
        
        Lrig1 [plasma membrane] (Rattus norvegicus)
      - USP8 deubiquitinates LRIG1 (Rattus norvegicus)
        
        MET:Ub-LRIG1 [plasma membrane] (Rattus norvegicus)
        
        Lrig1 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:M0RB60

Gene Names

Lrig1

Reference Genes

BioGPS Gene:312574 Lrig1

ENSEMBL:ENSRNOG00000012952

Monarch:312574 Lrig1

NCBI Gene:312574 Lrig1

UCSC:M0RB60 Lrig1

Reference Transcript

RefSeq:NM_001427801.1 Lrig1

Other Identifiers

10864279

1374652_at

1376547_at

17793418

312574

5704945

5709084

5733580

5750990

5775814

5784623

5885340

5918084

5959849

6062556

6077771

6160261

6215003

6243013

6331792

6340209

6378559

6423102

6461881

6464473

6470793

6477855

6711470

6729675

A_64_P023750

GE1266853

GO:0005515

GO:0007605

GO:0022405

GO:0032474

GO:0050877

GO:0060384

ILMN_1372023

PH_rn_0001324

Participates

as a component of

MET:Ub-LRIG1 [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Lrig1 [plasma membrane]

Inferred From

Ub-LRIG1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (Ub [cytosol]) at unknown position

Modification

Ub [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001414730.1

ENSEMBL

ENSRNOT00000072624, ENSRNOP00000066785, ENSRNOG00000012952

RGD

1306788

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