Reactome | Vamp8 [clathrin-coated endocytic vesicle membrane]

Vamp8 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869137

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP8, Q9WUF4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9WUF4

Gene Names

Vamp8

Reference Genes

BioGPS Gene:83730 Vamp8

ENSEMBL:ENSRNOG00000012748

ENSEMBL:ENSRNOG00055020802

ENSEMBL:ENSRNOG00060015579

ENSEMBL:ENSRNOG00065005266

KEGG:rno:83730 Vamp8

Monarch:83730 Vamp8

NCBI Gene:83730 Vamp8

UCSC:Q9WUF4 Vamp8

Reference Transcript

RefSeq:NM_031827.2 Vamp8

Other Identifiers

10863218

1369970_at

17792277

5651605

5714925

5731704

5889726

6222894

6624977

6636041

83730

A_43_P12697

GE13368

GO:0005737

GO:0005765

GO:0005768

GO:0005829

GO:0005886

GO:0016020

GO:0016192

GO:0016240

GO:0019869

GO:0030667

GO:0031201

GO:0031902

GO:0031982

GO:0035577

GO:0043226

GO:0046718

GO:0048471

GO:0055037

GO:0070254

GO:0097352

GO:0098594

GO:0098772

GO:1903076

GO:1903531

GO:1903595

ILMN_1360453

PH_rn_0014235

Participates

as a member of

VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

Vamp8 [secretory granule membrane]

Vamp8 [cytoplasmic vesicle membrane]

Vamp8 [Golgi membrane]

Vamp8 [lysosomal membrane]

Vamp8 [phagocytic vesicle membrane]

Vamp8 [recycling endosome membrane]

Vamp8 [tertiary granule membrane]

Vamp8 [specific granule membrane]

Vamp8 [plasma membrane]

Vamp8 [azurophil granule membrane]

Inferred From

VAMP8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_114015.1

ENSEMBL

ENSRNOT00000096938, ENSRNOG00000012748, ENSRNOP00000083978

PRO

Q9WUF4

RGD

620421

PDB

1GL2

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