Reactome | M6pr [clathrin-coated endocytic vesicle membrane]

M6pr [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869100

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

M6PR, Q6AY20

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of clathrin-associated proteins (Rattus norvegicus)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        M6pr [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6AY20

Gene Names

M6pr

Reference Genes

BioGPS Gene:100909548 M6pr

BioGPS Gene:312689 M6pr

ENSEMBL:ENSRNOG00000014992

ENSEMBL:ENSRNOG00000014992 M6pr

ENSEMBL:ENSRNOG00000059373

ENSEMBL:ENSRNOG00000059373 M6pr

KEGG Gene (Rattus norvegicus):100909548 M6pr

KEGG Gene (Rattus norvegicus):312689 M6pr

Monarch:100909548 M6pr

Monarch:312689 M6pr

NCBI Gene:100909548 M6pr

NCBI Gene:312689 M6pr

UCSC:Q6AY20 M6pr

Reference Transcript

Other Identifiers

100909548

10858487

10934772

1371495_at

17786877

17873700

312689

5851228

5989356

6078229

6097305

6248331

6337847

6357991

6396618

6556440

6633545

A_44_P260487

A_64_P067801

A_64_P067803

GE1205790

GO:0003674

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005794

GO:0006605

GO:0006622

GO:0006810

GO:0007034

GO:0008150

GO:0015031

GO:0019904

GO:0031410

GO:0043226

ILMN_1365228

PH_rn_0001736

PH_rn_0002945

rc_AA943990_at

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

M6pr [plasma membrane]

M6pr [Golgi membrane]

M6pr [lysosomal membrane]

M6pr [transport vesicle]

M6pr [trans-Golgi network membrane]

Inferred From

M6PR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_006257264.1, XP_006257263.1, XP_008761469.1, NP_001007701.1, XP_003752148.1

Ensembl

ENSRNOT00000020364, ENSRNOT00000088728, ENSRNOP00000069840, ENSRNOP00000020364, ENSRNOG00000059373, ENSRNOG00000014992

PRO

Q6AY20

RGD

6502964, 1359355

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