Reactome | Avpr2 [clathrin-coated endocytic vesicle membrane]

Avpr2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869077

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

AVPR2, Q00788

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Avpr2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q00788

Gene Names

Avpr2

Reference Genes

BioGPS Gene:25108 Avpr2

ENSEMBL:ENSRNOG00000059862

ENSEMBL:ENSRNOG00055024972

ENSEMBL:ENSRNOG00060006538

ENSEMBL:ENSRNOG00065014794

KEGG:rno:25108 Avpr2

Monarch:25108 Avpr2

NCBI Gene:25108 Avpr2

UCSC:Q00788 Avpr2

Reference Transcript

RefSeq:NM_019136.2 Avpr2

Other Identifiers

10936021

1369873_at

1371265_at

1393958_at

17875155

25108

5695286

6005909

6046456

6486950

6503146

6525572

6682852

A_43_P11944

A_64_P031890

GE20540

GO:0004930

GO:0005000

GO:0005768

GO:0005886

GO:0007186

GO:0007189

GO:0008285

GO:0016020

GO:0030139

GO:0031410

GO:0034097

GO:0038023

GO:0048471

GO:0070295

GO:1902533

ILMN_1373218

PH_rn_0005076

X83264exon_at

Z11932cds_at

Z11932cds_g_at

rc_AA819795_at

Participates

as a component of

AVPR2:AVP(20-28) [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

phospho-Avpr2 [plasma membrane]

Avpr2 [plasma membrane]

Inferred From

AVPR2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_062009.1

ZINC - Investigational

V2R_RAT

ENSEMBL

ENSRNOP00000071931, ENSRNOG00000059862, ENSRNOT00000091495

ZINC - Substances

V2R_RAT

ZINC target

Q00788

PRO

Q00788

GlyGen

Q00788

RGD

2186

ZINC - Predictions - Purchasable

V2R_RAT

PDB

2JX4

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