Reactome | Kctd7 [cytosol]

Kctd7 [cytosol]

Stable Identifier

R-RNO-8863184

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

KCTD7, B1WC97

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Kctd7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:B1WC97

Gene Names

Kctd7

Reference Genes

BioGPS Gene:688993 Kctd7

ENSEMBL:ENSRNOG00000042384

ENSEMBL:ENSRNOG00055000279

ENSEMBL:ENSRNOG00060010811

ENSEMBL:ENSRNOG00065001608

KEGG:rno:688993 Kctd7

Monarch:688993 Kctd7

NCBI Gene:688993 Kctd7

UCSC:B1WC97 Kctd7

Reference Transcript

RefSeq:NM_001128194.2 Kctd7

Other Identifiers

17677191

5917462

6110152

6357550

6421119

6429695

6473595

6496588

688993

A_43_P20754

A_64_P083159

GO:0005515

GO:0005737

GO:0005886

GO:0030007

GO:0051260

GO:0060081

GO:0065003

GO:0090461

ILMN_1375662

PH_rn_0003941

Participates

as a member of

BTB proteins [cytosol] (Rattus norvegicus)

Inferred From

KCTD7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001121666.1

ENSEMBL

ENSRNOT00000001198, ENSRNOG00000042384, ENSRNOP00000001198

PRO

B1WC97

RGD

1582914

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