Reactome | Rpl35al8 [cytosol]

Rpl35al8 [cytosol]

Stable Identifier

R-RNO-72462-2

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPL35A, D4A771

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Homologues of RPL35A [cytosol] (Rattus norvegicus)
        
        Rpl35al8 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A771

Gene Names

Rpl35al8

Reference Genes

ENSEMBL:ENSRNOG00000032348

ENSEMBL:ENSRNOG00000033058

ENSEMBL:ENSRNOG00000070978

ENSEMBL:ENSRNOG00000091059

UCSC:D4A771 Rpl35al8

Other Identifiers

10703375

10727462

10740558

10746952

10754694

10760018

10797473

108351255

10847995

10872093

10873916

10885205

1398760_at

17639123

17675613

17804158

17816571

5685128

5715652

5899726

5972965

6001203

6107933

6198439

6297718

6380303

6403113

6518298

6540883

6577118

6578039

A_64_P046994

A_64_P046998

A_64_P085690

A_64_P158298

GO:0003735

GO:0005198

GO:0005840

GO:0006412

ILMN_1351542

PH_rn_0024259

Participates

as a member of

Homologues of RPL35A [cytosol] (Rattus norvegicus)

Inferred From

RPL35A [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOT00000043587, ENSRNOG00000032348, ENSRNOP00000042068

RGD

11360540

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