Reactome | Cstf1 [nucleoplasm]

Cstf1 [nucleoplasm]

Stable Identifier

R-RNO-72001

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

CSTF1, Q5BJQ6

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - RNA Polymerase II Transcription Termination (Rattus norvegicus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)
      - CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Rattus norvegicus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)

Metabolism of RNA (Rattus norvegicus)

- Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
  - mRNA 3'-end processing (Rattus norvegicus)
    - mRNA Polyadenylation (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - Core CPA complex binds capped pre-mRNA (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - Formation of the CSTF complex (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - Formation of the core cleavage and polyadenylation complex (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - PP1 dephosphorylates RNA Pol II (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - RBBP6 activates CPSF complex (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        CPA complex [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF hexamer [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
- Processing of Capped Intronless Pre-mRNA (Rattus norvegicus)
  - Processing of Intronless Pre-mRNAs (Rattus norvegicus)
    - Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Rattus norvegicus)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Rattus norvegicus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
    - Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)
      - CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Rattus norvegicus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)
      - CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Rattus norvegicus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
    - Recruitment of CstF to the CPSF Bound Pre-mRNA (Rattus norvegicus)
      - CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)
        
        Cstf1 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5BJQ6

Gene Names

Cstf1

Reference Genes

BioGPS Gene:311670 Cstf1

ENSEMBL:ENSRNOG00000004775

ENSEMBL:ENSRNOG00055003464

ENSEMBL:ENSRNOG00060001159

ENSEMBL:ENSRNOG00065013965

KEGG:rno:311670 Cstf1

Monarch:311670 Cstf1

NCBI Gene:311670 Cstf1

UCSC:Q5BJQ6 Cstf1

Reference Transcript

Other Identifiers

10842517

1389348_at

1395767_at

17769253

311670

5636154

5655790

5690592

5828072

5837905

6173838

6199382

6560041

6584674

6648505

6673066

6682058

A_44_P241371

GE1255022

GE1280021

GO:0005515

GO:0005654

GO:0005848

GO:0016071

GO:0031124

PH_rn_0003353

rc_AA955587_at

Participates

as an input of

Formation of the CSTF complex (Rattus norvegicus)

as a component of

CSTF heterotrimer [nucleoplasm] (Rattus norvegicus)

Inferred From

CSTF1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006235744.1, XP_038961074.1, XP_006235743.4, NP_001402805.1, XP_006235745.1, XP_006235748.1, NP_001013179.1, NP_001402806.1

ENSEMBL

ENSRNOG00000004775, ENSRNOP00000051976, ENSRNOT00000055101

PRO

Q5BJQ6

RGD

1309267

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