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26S proteasome [cytosol]
Stable Identifier
R-RNO-68819
Type
Complex
Species
Rattus norvegicus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G1/S DNA Damage Checkpoints (Rattus norvegicus)
p53-Dependent G1/S DNA damage checkpoint (Rattus norvegicus)
p53-Dependent G1 DNA Damage Response (Rattus norvegicus)
Stabilization of p53 (Rattus norvegicus)
Autodegradation of the E3 ubiquitin ligase COP1 (Rattus norvegicus)
Proteasome mediated degradation of COP1 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
p53-Independent G1/S DNA damage checkpoint (Rattus norvegicus)
p53-Independent DNA Damage Response (Rattus norvegicus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Rattus norvegicus)
Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
M Phase (Rattus norvegicus)
Mitotic Metaphase and Anaphase (Rattus norvegicus)
Mitotic Anaphase (Rattus norvegicus)
Separation of Sister Chromatids (Rattus norvegicus)
Degradation of multiubiquitinated Securin (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Mitotic G2-G2/M phases (Rattus norvegicus)
G2/M Transition (Rattus norvegicus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Rattus norvegicus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
The role of GTSE1 in G2/M progression after G2 checkpoint (Rattus norvegicus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Regulation of mitotic cell cycle (Rattus norvegicus)
APC/C-mediated degradation of cell cycle proteins (Rattus norvegicus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Rattus norvegicus)
Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Rattus norvegicus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Rattus norvegicus)
APC/C:Cdc20 mediated degradation of Securin (Rattus norvegicus)
Degradation of multiubiquitinated Securin (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Rattus norvegicus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Rattus norvegicus)
Degradation multiubiquitinated Cyclin A (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Regulation of APC/C activators between G1/S and early anaphase (Rattus norvegicus)
SCF-beta-TrCP mediated degradation of Emi1 (Rattus norvegicus)
SCF-mediated degradation of Emi1 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
S Phase (Rattus norvegicus)
Synthesis of DNA (Rattus norvegicus)
Switching of origins to a post-replicative state (Rattus norvegicus)
CDK-mediated phosphorylation and removal of Cdc6 (Rattus norvegicus)
Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Orc1 removal from chromatin (Rattus norvegicus)
Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Ubiquitin-dependent degradation of Cyclin D (Rattus norvegicus)
Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
ub UBXN7 is degraded by the 26S proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
DNA Replication (Rattus norvegicus)
Synthesis of DNA (Rattus norvegicus)
Switching of origins to a post-replicative state (Rattus norvegicus)
CDK-mediated phosphorylation and removal of Cdc6 (Rattus norvegicus)
Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Orc1 removal from chromatin (Rattus norvegicus)
Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional regulation by RUNX1 (Rattus norvegicus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Rattus norvegicus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing-Cross presentation (Rattus norvegicus)
Cross-presentation of soluble exogenous antigens (endosomes) (Rattus norvegicus)
Proteasomal clevage of exogenous antigen (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Proteasomal cleavage of substrate (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Downstream signaling events of B Cell Receptor (BCR) (Rattus norvegicus)
Activation of NF-kappaB in B cells (Rattus norvegicus)
Ubiquitinated IkB is degraded (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
TNFR2 non-canonical NF-kB pathway (Rattus norvegicus)
26Sproteasome degrades K48polyUb-NIK (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
NIK-->noncanonical NF-kB signaling (Rattus norvegicus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
Dectin-1 mediated noncanonical NF-kB signaling (Rattus norvegicus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Metabolism of polyamines (Rattus norvegicus)
Regulation of ornithine decarboxylase (ODC) (Rattus norvegicus)
26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Metabolism of RNA (Rattus norvegicus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Rattus norvegicus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Rattus norvegicus)
AUF1:mRNA complex is destroyed (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
UCH proteinases (Rattus norvegicus)
ADRM1 binds 26S proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
ADRM1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
ADRM1:26S proteaseome binds UCHL5 (Rattus norvegicus)
ADRM1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
ADRM1:26S proteasome:UCHL5 [cytosol] (Rattus norvegicus)
ADRM1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)
ADRM1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
ADRM1:26S proteasome:USP14 [cytosol] (Rattus norvegicus)
ADRM1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Neddylation (Rattus norvegicus)
26S proteasome degrades HIFalpha (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
ub UBXN7 is degraded by the 26S proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN stability and activity (Rattus norvegicus)
Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
Regulation of RAS by GAPs (Rattus norvegicus)
NF1 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
MAPK6/MAPK4 signaling (Rattus norvegicus)
MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog 'off' state (Rattus norvegicus)
Degradation of GLI1 by the proteasome (Rattus norvegicus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
GLI3 is processed to GLI3R by the proteasome (Rattus norvegicus)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Hedgehog 'on' state (Rattus norvegicus)
ub-GLI is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Hedgehog ligand biogenesis (Rattus norvegicus)
Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
PCP/CE pathway (Rattus norvegicus)
Asymmetric localization of PCP proteins (Rattus norvegicus)
PRICKLE1 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Degradation of AXIN (Rattus norvegicus)
Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Degradation of DVL (Rattus norvegicus)
Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)
26S proteasome [cytosol] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Ghost homologue of PSMB11 [cytosol]
(Rattus norvegicus)
Ghost homologue of PSME3 [cytosol]
(Rattus norvegicus)
Ghost homologue of SEM1 [cytosol]
(Rattus norvegicus)
Homologues of PSMB6 [cytosol]
(Rattus norvegicus)
Psma1 [cytosol]
(Rattus norvegicus)
Psma2 [cytosol]
(Rattus norvegicus)
Psma3 [cytosol]
(Rattus norvegicus)
Psma4 [cytosol]
(Rattus norvegicus)
Psma5 [cytosol]
(Rattus norvegicus)
Psma6 [cytosol]
(Rattus norvegicus)
Psma7 [cytosol]
(Rattus norvegicus)
Psma8 [cytosol]
(Rattus norvegicus)
Psmb1 [cytosol]
(Rattus norvegicus)
Psmb10 [cytosol]
(Rattus norvegicus)
Psmb2 [cytosol]
(Rattus norvegicus)
Psmb3 [cytosol]
(Rattus norvegicus)
Psmb4 [cytosol]
(Rattus norvegicus)
PSMB5 [cytosol]
(Rattus norvegicus)
Psmb7 [cytosol]
(Rattus norvegicus)
Psmb8 [cytosol]
(Rattus norvegicus)
Psmb9 [cytosol]
(Rattus norvegicus)
PSMC1 [cytosol]
(Rattus norvegicus)
PSMC2 [cytosol]
(Rattus norvegicus)
PSMC3 [cytosol]
(Rattus norvegicus)
PSMC4 [cytosol]
(Rattus norvegicus)
PSMC5 [cytosol]
(Rattus norvegicus)
Psmc6 [cytosol]
(Rattus norvegicus)
Psmd1 [cytosol]
(Rattus norvegicus)
Psmd10 [cytosol]
(Rattus norvegicus)
Psmd11 [cytosol]
(Rattus norvegicus)
Psmd12 [cytosol]
(Rattus norvegicus)
Psmd13 [cytosol]
(Rattus norvegicus)
Psmd14 [cytosol]
(Rattus norvegicus)
Psmd2 [cytosol]
(Rattus norvegicus)
Psmd3 [cytosol]
(Rattus norvegicus)
PSMD4 [cytosol]
(Rattus norvegicus)
Psmd5 [cytosol]
(Rattus norvegicus)
Psmd6 [cytosol]
(Rattus norvegicus)
Psmd7 [cytosol]
(Rattus norvegicus)
Psmd8 [cytosol]
(Rattus norvegicus)
Psmd9 [cytosol]
(Rattus norvegicus)
Psme1 [cytosol]
(Rattus norvegicus)
Psme2 [cytosol]
(Rattus norvegicus)
Psme4 [cytosol]
(Rattus norvegicus)
Psmf1 [cytosol]
(Rattus norvegicus)
Participates
as a component of
ADRM1:26S proteasome [cytosol] (Rattus norvegicus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Rattus norvegicus)
as an input of
ADRM1 binds 26S proteasome (Rattus norvegicus)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)
as an output of
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)
Inferred From
26S proteasome [cytosol]
(Homo sapiens)
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