Reactome | FAAP20 [nucleoplasm]

FAAP20 [nucleoplasm]

Stable Identifier

R-RNO-6783321

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

D4AAA5

Locations in the PathwayBrowser

Expand all

DNA Repair (Rattus norvegicus)

- Fanconi Anemia Pathway (Rattus norvegicus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - POLN binds ICL-DNA (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
  - Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP20 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
      - FAAP20 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4AAA5

Reference Genes

BioGPS Gene:362678

ENSEMBL:ENSRNOG00000036876

ENSEMBL:ENSRNOG00055015052

ENSEMBL:ENSRNOG00060004143

ENSEMBL:ENSRNOG00065009716

KEGG:rno:362678

Monarch:362678

NCBI Gene:362678

UCSC:D4AAA5

Reference Transcript

RefSeq:NM_001108698.1

Other Identifiers

10874585

1388706_at

17804856

362678

5644486

5906184

6067484

6704824

A_44_P279222

A_44_P279224

GE12818

GO:0000785

GO:0005634

GO:0005694

GO:0006281

GO:0006974

GO:0008270

GO:0019985

GO:0031593

GO:0036297

GO:0043130

GO:0043240

GO:0046872

GO:0060090

GO:0070530

GO:0140036

ILMN_1360281

rc_AA944052_at

Participates

as a component of

Other forms of this molecule

FAAP20 [cytosol]

Inferred From

FAAP20 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001102168.1

ENSEMBL

ENSRNOP00000052229, ENSRNOG00000036876, ENSRNOT00000055361

PRO

D4AAA5

RGD

1308923

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