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Isy1 [nucleoplasm]
Stable Identifier
R-RNO-6781963
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
ISY1, Q6AYB3
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Nucleotide Excision Repair (Rattus norvegicus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Dual incision in TC-NER (Rattus norvegicus)
3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
XAB2 complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Metabolism of RNA (Rattus norvegicus)
Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
mRNA Splicing (Rattus norvegicus)
mRNA Splicing - Major Pathway (Rattus norvegicus)
Formation of the Spliceosomal B* complex (Rattus norvegicus)
Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Spliceosomal Bact complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Formation of the Spliceosomal C complex containing intron lariat (Rattus norvegicus)
Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Formation of the Spliceosomal C* complex (Rattus norvegicus)
Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)
Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Rattus norvegicus)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Isy1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q6AYB3
Gene Names
Isy1
Reference Genes
BioGPS Gene:362394 Isy1
ENSEMBL:ENSRNOG00000010021
ENSEMBL:ENSRNOG00000037768
ENSEMBL:ENSRNOG00055012975
ENSEMBL:ENSRNOG00060024260
ENSEMBL:ENSRNOG00065015091
KEGG:rno:362394 Isy1
Monarch:362394 Isy1
NCBI Gene:362394 Isy1
UCSC:Q6AYB3 Isy1
Reference Transcript
RefSeq:NM_001014188.1 Isy1
Other Identifiers
10863851
10863857
1383596_at
1385539_at
1394486_at
17793003
17793009
362394
500249
5724760
5737560
5764226
5851688
5891593
5933895
5989860
6074390
6078148
6081371
6083660
6245853
6247966
6267500
6302634
6303163
6384528
6426777
6558985
A_44_P161602
A_44_P467057
A_64_P102410
GE1206644
GE15462
GE16749
GO:0000350
GO:0000389
GO:0000398
GO:0000974
GO:0003924
GO:0005525
GO:0005634
GO:0005681
GO:0006397
GO:0008380
GO:0016071
GO:0016787
GO:0065003
GO:0071006
GO:0071013
GO:0071014
GO:0071020
ILMN_1358940
PH_rn_0002876
rc_AI136869_at
Participates
as a component of
XAB2 complex [nucleoplasm] (Rattus norvegicus)
PRP19-CDC5L related complex [nucleoplasm] (Rattus norvegicus)
Inferred From
ISY1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001014210.1
ENSEMBL
ENSRNOG00000037768
,
ENSRNOP00000013571
,
ENSRNOT00000013571
PRO
Q6AYB3
RGD
1307688
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