Reactome | Serpina1 [endoplasmic reticulum lumen]

Serpina1 [endoplasmic reticulum lumen]

Stable Identifier

R-RNO-5689435

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

endoplasmic reticulum lumen

Synonyms

(Glc)3(GlcNAc)2(Man)9-SERPINA1, P17475

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPII-mediated vesicle transport (Rattus norvegicus)
        
        Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Loss of SAR1B GTPase (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Cargo concentration in the ER (Rattus norvegicus)
        
        Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        LMAN family proteins bind glycosylated cargo (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPII-mediated vesicle transport (Rattus norvegicus)
      - Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
      - Loss of SAR1B GTPase (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
      - Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
    - Cargo concentration in the ER (Rattus norvegicus)
      - Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
      - LMAN family proteins bind glycosylated cargo (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Serpina1 [endoplasmic reticulum lumen] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P17475

Gene Names

Serpina1

Reference Genes

BioGPS Gene:24648 Serpina1

ENSEMBL:ENSRNOG00000032669

KEGG:rno:24648 Serpina1

Monarch:24648 Serpina1

NCBI Gene:24648 Serpina1

UCSC:P17475 Serpina1

Participates

as a member of

glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)

Other forms of this molecule

Serpina1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Serpina1 [COPII-coated ER to Golgi transport vesicle]

Serpina1 [ficolin-1-rich granule lumen]

phospho-Serpina1 [endoplasmic reticulum lumen]

Serpina1 [endoplasmic reticulum lumen]

Serpina1 [extracellular region]

Serpina1 [platelet alpha granule lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

PRO

P17475

GlyGen

P17475

RGD

3326

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