Reactome | Ctsz [endoplasmic reticulum lumen]

Ctsz [endoplasmic reticulum lumen]

Stable Identifier

R-RNO-5689431

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

endoplasmic reticulum lumen

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSZ, Q9R1T3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPII-mediated vesicle transport (Rattus norvegicus)
        
        Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Loss of SAR1B GTPase (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Cargo concentration in the ER (Rattus norvegicus)
        
        Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        LMAN family proteins bind glycosylated cargo (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPII-mediated vesicle transport (Rattus norvegicus)
      - Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
      - Loss of SAR1B GTPase (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
      - Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
    - Cargo concentration in the ER (Rattus norvegicus)
      - Inner coat assembly and cargo binding (Rattus norvegicus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
      - LMAN family proteins bind glycosylated cargo (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)
        
        Ctsz [endoplasmic reticulum lumen] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9R1T3

Gene Names

Ctsz

Reference Genes

BioGPS Gene:252929 Ctsz

ENSEMBL:ENSRNOG00000050697

ENSEMBL:ENSRNOG00055000704

ENSEMBL:ENSRNOG00060001193

ENSEMBL:ENSRNOG00065013252

KEGG:rno:252929 Ctsz

Monarch:252929 Ctsz

NCBI Gene:252929 Ctsz

UCSC:Q9R1T3 Ctsz

Reference Transcript

RefSeq:NM_183330.2 Ctsz

Other Identifiers

10940594

1370885_at

17882637

17882638

252929

5940837

6030544

6322659

A_44_P428420

GE13088

GO:0004180

GO:0004197

GO:0005576

GO:0005615

GO:0005764

GO:0005783

GO:0005938

GO:0006508

GO:0008233

GO:0008234

GO:0009986

GO:0010757

GO:0016787

GO:0016807

GO:0030426

GO:0031410

GO:0051603

GO:0060441

PH_rn_0015028

rc_AA818798_at

rc_AA851184_s_at

Participates

as a member of

glycosylated LMAN cargo [endoplasmic reticulum lumen] (Rattus norvegicus)

Other forms of this molecule

Ctsz [Golgi lumen]

Ctsz [lysosomal lumen]

Ctsz [endoplasmic reticulum-Golgi intermediate compartment membrane]

Ctsz [COPII-coated ER to Golgi transport vesicle]

Ctsz [specific granule lumen]

Ctsz [extracellular region]

Ctsz [ficolin-1-rich granule lumen]

Ctsz [plasma membrane]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

RefSeq

NP_899159.1

ENSEMBL

ENSRNOP00000066523, ENSRNOG00000050697, ENSRNOT00000072069

PRO

Q9R1T3

GlyGen

Q9R1T3

RGD

708479

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