Reactome | UIMC1 [nucleoplasm]

UIMC1 [nucleoplasm]

Stable Identifier

R-RNO-5682574

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

Q5PQK4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - G2/M DNA damage checkpoint (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)

DNA Repair (Rattus norvegicus)

- DNA Double-Strand Break Repair (Rattus norvegicus)
  - DNA Double Strand Break Response (Rattus norvegicus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - CHEK2 phosphorylates BRCA1 (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
  - Homology Directed Repair (Rattus norvegicus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
      - Processing of DNA double-strand break ends (Rattus norvegicus)
        
        PIAS4 SUMOylates MDC1 (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
  - Nonhomologous End-Joining (NHEJ) (Rattus norvegicus)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        UIMC1 [nucleoplasm] (Rattus norvegicus)
      - UIMC1 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5PQK4

Reference Genes

BioGPS Gene:290997

ENSEMBL:ENSRNOG00000016891

ENSEMBL:ENSRNOG00055013752

ENSEMBL:ENSRNOG00060018934

ENSEMBL:ENSRNOG00065025177

KEGG:rno:290997

Monarch:290997

NCBI Gene:290997

UCSC:Q5PQK4

Reference Transcript

Other Identifiers

10794099

1398995_at

17714488

290997

5628271

5660140

5707929

5721065

5794783

5812324

5816459

5867192

5908572

5938301

5946623

6056284

6057703

6195354

6299432

6320618

6339755

6438410

6513847

6515862

6520805

6540792

6556527

A_64_P153040

GE16272

GO:0003677

GO:0005634

GO:0005654

GO:0006281

GO:0006302

GO:0006325

GO:0006355

GO:0006974

GO:0007095

GO:0008270

GO:0010212

GO:0016604

GO:0035861

GO:0042393

GO:0045739

GO:0045892

GO:0046872

GO:0060090

GO:0061649

GO:0070530

GO:0070531

GO:0140861

ILMN_1358989

PH_rn_0002003

rc_AI146170_at

Participates

as an output of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)

as a component of

as an input of

UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)

Inferred From

UIMC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001013906.1, XP_038951399.1, XP_063132216.1, XP_038951400.1, XP_063132215.1

ENSEMBL

ENSRNOP00000022704, ENSRNOG00000016891, ENSRNOT00000022703

PRO

Q5PQK4

RGD

1307009

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