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phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
Stable Identifier
R-RNO-5672648
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
P14056
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
RAF activation (Rattus norvegicus)
Phosphorylation of RAF (Rattus norvegicus)
RAF activating kinases [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P14056 Araf
Gene Names
Araf, A-raf, Araf1
Chain
chain:1-604
Reference Genes
BioGPS Gene:64363 Araf
ENSEMBL:ENSRNOG00000010838.6 Araf
KEGG Gene (Rattus norvegicus):64363 Araf
Monarch:64363 Araf
NCBI Gene:64363 Araf
UCSC:P14056 Araf
Reference Transcript
RefSeq:NM_022532.2 Araf
Other Identifiers
10936488
1368390_at
17875672
5645822
5666416
5730000
5788065
5832118
5968659
5970237
5998336
6022541
6054506
6055377
6086502
6287891
6290438
6433674
64363
6499610
6513293
6554310
6568771
6652242
6732749
6733113
A_44_P211440
A_64_P109880
A_64_P150696
A_64_P150699
GE1145981
GE22099
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005739
GO:0006468
GO:0007165
GO:0012501
GO:0016740
GO:0023052
GO:0030163
GO:0032006
GO:0032434
GO:0033138
GO:0036211
GO:0043066
GO:0043226
GO:0140096
ILMN_1352852
PH_rn_0003489
X06942_at
rc_AI227665_s_at
Participates
as a candidate of
RAF activating kinases [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
A-Raf proto-oncogene serine/threonine-protein kinase [cytosol]
phospho-p-S214,S582 ARAF [cytosol]
phospho-p-S582 ARAF [cytosol]
phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol]
Inferred From
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 582 (in Homo sapiens)
Coordinate
582
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 299 (in Homo sapiens)
Coordinate
299
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 302 (in Homo sapiens)
Coordinate
302
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-threonine at 452 (in Homo sapiens)
Coordinate
452
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 455 (in Homo sapiens)
Coordinate
455
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_071977.1
IntEnz
2.7.11.1
Ensembl
ENSRNOP00000048890
,
ENSRNOG00000010838
,
ENSRNOT00000039911
PRO
P14056
RGD
2148
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