Reactome | ADCY8 [plasma membrane]

ADCY8 [plasma membrane]

Stable Identifier

R-RNO-53245

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P40146

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - GABA receptor activation (Rattus norvegicus)
      - GABA B receptor activation (Rattus norvegicus)
        
        Activation of GABAB receptors (Rattus norvegicus)
        
        Adenylate cyclase inhibitory pathway (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - DAG and IP3 signaling (Rattus norvegicus)
    - CaM pathway (Rattus norvegicus)
      - Calmodulin induced events (Rattus norvegicus)
        
        PKA-mediated phosphorylation of CREB (Rattus norvegicus)
        
        PKA activation (Rattus norvegicus)
        
        Adenylate cyclase produces cAMP (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Opioid Signalling (Rattus norvegicus)
        
        G-protein mediated events (Rattus norvegicus)
        
        Adenylate cyclase activating pathway (Rattus norvegicus)
        
        Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase inhibitory pathway (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        PLC beta mediated events (Rattus norvegicus)
        
        Ca-dependent events (Rattus norvegicus)
        
        CaM pathway (Rattus norvegicus)
        
        Calmodulin induced events (Rattus norvegicus)
        
        PKA-mediated phosphorylation of CREB (Rattus norvegicus)
        
        PKA activation (Rattus norvegicus)
        
        Adenylate cyclase produces cAMP (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
    - G alpha (z) signalling events (Rattus norvegicus)
      - G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)
- Signaling by Hedgehog (Rattus norvegicus)
  - Hedgehog 'off' state (Rattus norvegicus)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)
      - adenylate cyclases:Mg2+ [plasma membrane] (Rattus norvegicus)
        
        adenylate cyclases [plasma membrane] (Rattus norvegicus)
        
        ADCY8 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P40146 Adcy8

Gene Names

Adcy8

Chain

chain:1-1248

Reference Genes

BioGPS Gene:29241 Adcy8

KEGG:rno:29241 Adcy8

Monarch:29241 Adcy8

NCBI Gene:29241 Adcy8

UCSC:P40146 Adcy8

Reference Transcript

RefSeq:NM_017142.1 Adcy8

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Rattus norvegicus)

as a member of

Adenylate cyclase [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Adcy8 [plasma membrane]

Inferred From

ADCY8 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_058838.1

IntEnz

4.6.1.1

PRO

P40146

GlyGen

P40146

RGD

2036

HMDB Protein

HMDBP14646

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