Reactome | Mbd3 [nucleoplasm]

Mbd3 [nucleoplasm]

Stable Identifier

R-RNO-4657010

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

MBD3, F7EY92

Locations in the PathwayBrowser

Expand all

Chromatin organization (Rattus norvegicus)

- ATP-dependent chromatin remodelers (Rattus norvegicus)
  - CHD chromatin remodelers (Rattus norvegicus)
    - CHD3, CHD4, CHD5 subfamily (Rattus norvegicus)
      - NuRD complex assembly (Rattus norvegicus)
        
        CHD and CDK2AP subunits are recruited to NuRD (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        Interaction of NuRD complexes with transcription factors (Rattus norvegicus)
        
        GATAD2A NuRD binds ZMYND8:ZNF532:ZNF592:ZNF687 (Rattus norvegicus)
        
        GATAD2A NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4, RBBP7:MBD2,MBD3:GATAD2A [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        ZMYND8:ZNF532:ZNF592:ZNF687:GATAD2A NuRD [nucleoplasm] (Rattus norvegicus)
        
        GATAD2A NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4, RBBP7:MBD2,MBD3:GATAD2A [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD binds Ikaros family member proteins (Rattus norvegicus)
        
        IKZF1,IKZF2,IKZF3:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD binds TCF19 at FBP1 gene (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        TCF19:NuRD:FBP1 gene:H3K4 nucleosome [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD binds TCF19 at G6PC gene (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        TCF19:NuRD:G6PC gene:H3K4 nucleosome [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD binds TCF19 at PCK1 gene (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        TCF19:NuRD:PCK1 gene:H3K4 nucleosome [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD deacetylates telomeric nucleosomes (Rattus norvegicus)
        
        NR2C2,NR2F2:ZNF827:NuRD:H4K5,H4K8 Ac telomeric chromatin [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NR2C2,NR2F2:ZNF827:NuRD:telomeric chromatin [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        PHF6 binds NuRD (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        PHF6:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        ZNF827 and NR2C2,NR2F2 recruit NuRD to telomeric chromatin (Rattus norvegicus)
        
        NR2C2,NR2F2:ZNF827:NuRD:H4K5,H4K8 Ac telomeric chromatin [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        NuRD [nucleoplasm] (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex (Rattus norvegicus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        MBD3L2 binds MBD3 NuRD core complex (Rattus norvegicus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4,BBP7:MBD3:GATAD2A,GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        MBD3L2:HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4,RBBP7:MBD3:GATAD2A,GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4,BBP7:MBD3:GATAD2A,GATAD2B [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
- Chromatin modifying enzymes (Rattus norvegicus)
  - HDACs deacetylate histones (Rattus norvegicus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
    - HDAC1:2-containing complex deacetylate histones (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase I Transcription (Rattus norvegicus)
  - RNA Polymerase I Promoter Clearance (Rattus norvegicus)
    - RNA Polymerase I Transcription Initiation (Rattus norvegicus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - Regulation of TP53 Activity (Rattus norvegicus)
        
        Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
        
        MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
        
        MTA2-NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - PTEN Regulation (Rattus norvegicus)
      - Regulation of PTEN gene transcription (Rattus norvegicus)
        
        SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F7EY92

Gene Names

Mbd3

Reference Genes

BioGPS Gene:362834 Mbd3

ENSEMBL:ENSRNOG00000028956

Monarch:362834 Mbd3

NCBI Gene:362834 Mbd3

UCSC:F7EY92 Mbd3

Reference Transcript

RefSeq:NM_001439500.1 Mbd3

Other Identifiers

10893852

17826393

362834

5694732

5861885

5964615

6108631

6386004

6387099

6423223

6551153

A_44_P272324

A_64_P030554

GO:0000122

GO:0000785

GO:0000792

GO:0001701

GO:0003229

GO:0003677

GO:0005634

GO:0005654

GO:0005737

GO:0006325

GO:0006338

GO:0006346

GO:0006355

GO:0008327

GO:0009888

GO:0016581

GO:0031667

GO:0032355

GO:0032991

GO:0040029

GO:0048568

GO:0048856

GO:1903925

ILMN_1359297

Participates

as a component of

as a member of

MBD2,MBD3 [nucleoplasm] (Rattus norvegicus)

Inferred From

MBD3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001426429.1

ENSEMBL

ENSRNOT00000049170, ENSRNOG00000028956, ENSRNOP00000041242

RGD

1307389

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