Reactome | MAPK10 [cytosol]

MAPK10 [cytosol]

Stable Identifier

R-RNO-450352

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P49187

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-17 signaling (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
    - FCERI mediated MAPK activation (Rattus norvegicus)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
        
        MAPK8,9,10 [cytosol] (Rattus norvegicus)
        
        MAPK10 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P49187

Reference Genes

BioGPS Gene:25272

ENSEMBL:ENSRNOG00000002079

KEGG:rno:25272

Monarch:25272

NCBI Gene:25272

UCSC:P49187

Reference Transcript

Participates

as a member of

MAPK8,9,10 [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-p-T221,Y223-MAPK10 [cytosol]

phospho-p-T221,Y223-MAPK10 [nucleoplasm]

Inferred From

MAPK10 [cytosol] (Homo sapiens)

Cross References

IntEnz

2.7.11.24

ZINC - Substances

MK10_RAT

ZINC target

P49187

PRO

P49187

RGD

3663

ZINC - Predictions - Purchasable

MK10_RAT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29067	3	Arrb2 [endocytic vesicle membrane] (R-RNO-9910881) Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.508	3

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