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phospho-p-S172-IKBKE [cytosol]
Stable Identifier
R-RNO-450278
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
D4A5E7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Rattus norvegicus)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Rattus norvegicus)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Rattus norvegicus)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
phospho-p-S172-IKBKE [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D4A5E7
Reference Genes
ENSEMBL:ENSRNOG00000025100
KEGG:rno:363984
UCSC:D4A5E7
Other Identifiers
10767518
17684052
363984
5618603
5638996
5647519
5713972
5783241
5811436
5847064
5853516
5874787
5890940
5988082
6167210
6240680
6277638
6306750
6381547
6418570
6435925
6446222
6454145
6456243
6553411
6594392
6604024
6631611
6680760
A_42_P667960
A_44_P496706
GE1267743
GO:0000166
GO:0002218
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005737
GO:0006468
GO:0006950
GO:0006955
GO:0006974
GO:0008384
GO:0008630
GO:0010467
GO:0010628
GO:0010884
GO:0016301
GO:0016605
GO:0016740
GO:0031625
GO:0031966
GO:0032481
GO:0034097
GO:0034340
GO:0035456
GO:0035556
GO:0036435
GO:0042802
GO:0043123
GO:0043254
GO:0048255
GO:0060337
GO:0060340
GO:0097400
GO:0098586
GO:0140096
ILMN_1357139
PH_rn_0008789
rc_AI030681_at
Participates
as a component of
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
phospho-p-S172-IKBKE [nucleoplasm]
K63polyUb-K30,K401-IKBKE [cytosol]
IKBKE [cytosol]
Inferred From
p-S172-IKBKE [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 172 (in Homo sapiens)
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ENSEMBL
ENSRNOT00000038151
,
ENSRNOP00000030127
,
ENSRNOG00000025100
RGD
1308352
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