Reactome | Jun [nucleoplasm]

Jun [nucleoplasm]

Stable Identifier

R-RNO-450250

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

JUN, P17325

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-17 signaling (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
    - FCERI mediated MAPK activation (Rattus norvegicus)
      - Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        Activation of the AP-1 family of transcription factors (Rattus norvegicus)
        
        Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Nuclear Receptors (Rattus norvegicus)
  - ESR-mediated signaling (Rattus norvegicus)
    - Estrogen-dependent gene expression (Rattus norvegicus)
      - Binding of AP1 transcriptional activator complexes to CCND1 promoter (Rattus norvegicus)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Rattus norvegicus)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Rattus norvegicus)
        
        FOS:JUN [nucleoplasm] (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Rattus norvegicus)
        
        FOS:JUN [nucleoplasm] (Rattus norvegicus)
        
        Jun [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P17325

Gene Names

Jun

Reference Genes

BioGPS Gene:24516 Jun

ENSEMBL:ENSRNOG00000026293

ENSEMBL:ENSRNOG00055007293

ENSEMBL:ENSRNOG00060014128

ENSEMBL:ENSRNOG00065018436

KEGG:rno:24516 Jun

Monarch:24516 Jun

NCBI Gene:24516 Jun

UCSC:P17325 Jun

Reference Transcript

RefSeq:NM_021835.3 Jun

Other Identifiers

10878112

1369788_s_at

1374404_at

1389528_s_at

17808683

24516

5762249

5788789

5957840

5987473

6027652

6098701

6155367

6231770

6249635

6285488

6342333

6358875

6485592

6685920

6703147

6725675

A_42_P741027

A_64_P053353

GE16423

GO:0000976

GO:0000978

GO:0001228

GO:0001525

GO:0001774

GO:0001889

GO:0001938

GO:0002376

GO:0003151

GO:0003677

GO:0003682

GO:0003700

GO:0005634

GO:0005667

GO:0006355

GO:0006915

GO:0007254

GO:0008283

GO:0008285

GO:0009410

GO:0010634

GO:0017053

GO:0030154

GO:0030224

GO:0031103

GO:0035026

GO:0035976

GO:0035994

GO:0043066

GO:0043524

GO:0045944

GO:0048146

GO:0048856

GO:0051726

GO:0061029

GO:0070374

GO:0071277

GO:0072740

ILMN_1365705

PH_rn_0012337

PH_rn_0023699

X17163cds_s_at

rc_AA945867_at

rc_AI175959_at

Participates

as an input of

Activated JNKs phosphorylate c-JUN (Rattus norvegicus)

as a component of

FOS:JUN [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

phospho-Jun [nucleoplasm]

Inferred From

JUN [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOP00000011732, ENSRNOT00000011731, ENSRNOG00000026293

ZINC - Substances

JUN_RAT

ZINC target

P17325

PRO

P17325

GlyGen

P17325

RGD

2943

ZINC - Predictions - Purchasable

JUN_RAT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12841 Fos	2	phospho-Fos [nucleoplasm] (R-RNO-450283) Fos [nucleoplasm] (R-RNO-3261165)	0.589	2

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