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Tollip [cytosol]
Stable Identifier
R-RNO-446885
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
TOLLIP, A2RUW1
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IRAK4 is activated by autophosphorylation (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IRAK4 phosphorylates IRAK1 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
Tollip [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A2RUW1
Gene Names
Tollip
Reference Genes
BioGPS Gene:361677 Tollip
ENSEMBL:ENSRNOG00000019861
KEGG:rno:361677 Tollip
Monarch:361677 Tollip
NCBI Gene:361677 Tollip
UCSC:A2RUW1 Tollip
Reference Transcript
RefSeq:NM_001109668.1 Tollip
Other Identifiers
10726916
1378572_at
1380808_at
1399052_at
17638494
361677
5617857
5977335
6085971
6189453
6393338
6474066
6498291
6563899
6648295
6678503
A_44_P262569
A_44_P834980
GE1158184
GE1284245
GE14637
GO:0005515
GO:0007165
GO:0016310
GO:0019900
GO:0023052
GO:0030154
GO:0030855
GO:0032991
GO:0035325
GO:0036010
GO:0043130
GO:0048856
GO:0060090
GO:0070498
ILMN_1371790
PH_rn_0004977
rc_AA956943_at
rc_AI227705_at
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
as an input of
The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)
as a component of
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Tollip [specific granule lumen]
Tollip [extracellular region]
Tollip [azurophil granule lumen]
Inferred From
TOLLIP [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSRNOG00000019861
,
ENSRNOP00000049498
,
ENSRNOT00000046344
PRO
A2RUW1
RGD
1304676
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