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phospho-p-T342,T345,S346-IRAK4 [cytosol]
Stable Identifier
R-RNO-446649
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
A0A8I6G1H3
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IRAK4 is activated by autophosphorylation (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IRAK4 phosphorylates IRAK1 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6G1H3
Reference Genes
BioGPS Gene:300177
ENSEMBL:ENSRNOG00000005965
KEGG:rno:300177
Monarch:300177
NCBI Gene:300177
UCSC:A0A8I6G1H3
Reference Transcript
RefSeq:NM_001106791.2
RefSeq:XM_006242193.3
Other Identifiers
10898862
17831923
300177
5705991
5716364
5726491
5813930
5928609
6076043
6092597
6120597
6153126
6166148
6353884
6494454
6502141
6583558
6599044
6611278
6719791
A_44_P220575
A_44_P671842
GE1111849
GO:0000287
GO:0002376
GO:0002446
GO:0003824
GO:0004672
GO:0004674
GO:0005149
GO:0005524
GO:0006468
GO:0007165
GO:0009986
GO:0016301
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0036211
GO:0038172
GO:0043123
GO:0048870
GO:0070498
GO:0140096
GO:1990266
ILMN_1360142
PH_rn_0015748
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
IRAK4 [cytosol]
Inferred From
p-T342,T345,S346-IRAK4 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 342 (in Homo sapiens)
Coordinate
342
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 346 (in Homo sapiens)
Coordinate
346
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001100261.2
,
XP_006242255.1
ENSEMBL
ENSRNOP00000078243
,
ENSRNOT00000104284
,
ENSRNOG00000005965
RGD
1305303
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