Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SLC6A4 [plasma membrane]
Stable Identifier
R-RNO-444015
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
P31652
Locations in the PathwayBrowser
Expand all
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter clearance (Rattus norvegicus)
Serotonin clearance from the synaptic cleft (Rattus norvegicus)
SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)
SLC6A4 [plasma membrane] (Rattus norvegicus)
SLC6A4:TCAs and SSRIs [plasma membrane] (Rattus norvegicus)
SLC6A4 [plasma membrane] (Rattus norvegicus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A4 [plasma membrane] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
SLC-mediated transport of neurotransmitters (Rattus norvegicus)
Reuptake of serotonin from the synapse (Rattus norvegicus)
SLC6A4 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P31652
Reference Genes
BioGPS Gene:25553
ENSEMBL:ENSRNOG00000003476
ENSEMBL:ENSRNOG00055025018
ENSEMBL:ENSRNOG00060018174
KEGG:rno:25553
Monarch:25553
NCBI Gene:25553
UCSC:P31652
Reference Transcript
RefSeq:XM_008767950.4
RefSeq:XM_017597041.3
RefSeq:XM_039085288.2
RefSeq:XM_017597042.3
RefSeq:NM_013034.4
Other Identifiers
10745438
1368348_at
17659156
25553
5733123
5798129
5870387
5901558
5988306
6049526
6065827
6076955
6155817
6172677
6207732
6248646
6255593
6371671
6459584
6469161
6483698
6552832
6644834
6645766
6652552
A_44_P477866
A_44_P477871
GE20129
GE22159
GO:0005178
GO:0005326
GO:0005335
GO:0005886
GO:0005925
GO:0006836
GO:0006837
GO:0008504
GO:0009636
GO:0010628
GO:0012505
GO:0015297
GO:0015844
GO:0016020
GO:0031402
GO:0045121
GO:0045202
GO:0045787
GO:0046621
GO:0048484
GO:0048854
GO:0048856
GO:0050998
GO:0051378
GO:0051610
GO:0070527
GO:0090067
GO:0098810
PH_rn_0011476
PH_rn_0022155
X63253cds_s_at
X63995_at
Participates
as an input of
SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)
as a component of
SLC6A4:TCAs and SSRIs [plasma membrane] (Rattus norvegicus)
Inferred From
SLC6A4 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_038941216.1
,
XP_008766172.1
,
XP_017452530.1
,
XP_017452531.1
,
NP_037166.2
ZINC - World Drugs
SC6A4_RAT
ENSEMBL
ENSRNOG00000003476
,
ENSRNOT00000004717
,
ENSRNOP00000004717
ZINC - FDA approved
SC6A4_RAT
ZINC - Substances
SC6A4_RAT
ZINC - Biogenic
SC6A4_RAT
ZINC target
P31652
PRO
P31652
GlyGen
P31652
RGD
3714
ZINC - Investigational
SC6A4_RAT
ZINC - Metabolites
SC6A4_RAT
ZINC - Predictions - Purchasable
SC6A4_RAT
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9JJK1 GPM6B
0.463
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text