Reactome | VEGFA-165 dimer [extracellular region]

VEGFA-165 dimer [extracellular region]

Stable Identifier

R-RNO-4420158

Type

Complex

Species

Rattus norvegicus

Compartment

extracellular region

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by VEGF (Rattus norvegicus)
    - VEGFA-VEGFR2 Pathway (Rattus norvegicus)
      - AXL autophosphorylates on Y779 and Y821 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - AXL binds SRC-1 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - CDC42:GTP binds PAK2 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - CRK binds BCAR1 and or PXN (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - FYN autophosphorylates (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - FYN phosphorylates PAK2 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PAK2 autophorylates (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PAK2 binds NCK (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PTK2 autophosphorylates (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PTK2beta binds alphaVbeta3 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - Phosphorylation of SRC-1 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - SRC-1 phosphorylates SHB (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - SRC-1 phosphorylates p-Y397-PTK2 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - Src kinases phosphorylate VAV (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - VEGFA-165 dimer binds VEGFA inhibitors (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA-165 dimer:VEGFA inhibitors [extracellular region] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA-165 dimer:VEGFA inhibitors [extracellular region] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA-165 dimer:VEGFR2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - VEGFR2 autophosphorylates (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA-165 dimer:VEGFR2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - VEGFR2 mediated cell proliferation (Rattus norvegicus)
        
        PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        SFKs phosphorylate PLCG1 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-6Y-VEGFR2 binds FYN (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-6Y-VEGFR2 binds NCK (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-6Y-VEGFR2 binds SHB (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SHC2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-AXL binds PI3K (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p-Y420-FYN is phosphorylated on S21 (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)
      - p38 MAPK activation by VEGFR (Rattus norvegicus)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] (Rattus norvegicus)
        
        VEGFA-165 dimer [extracellular region] (Rattus norvegicus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 Vegfa [extracellular region] (Rattus norvegicus)

Participates

as an input of

as a component of

Inferred From

VEGFA-165 dimer [extracellular region] (Homo sapiens)

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