Reactome | Fancc [nucleoplasm]

Fancc [nucleoplasm]

Stable Identifier

R-RNO-419530

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

FANCC, O35870

Locations in the PathwayBrowser

Expand all

DNA Repair (Rattus norvegicus)

- Fanconi Anemia Pathway (Rattus norvegicus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - POLN binds ICL-DNA (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
  - Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Fancc [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
      - Fancc [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O35870

Gene Names

Fancc

Reference Genes

ENSEMBL:ENSRNOG00000016889

UCSC:O35870 Fancc

Participates

as a component of

Other forms of this molecule

Fancc [cytosol]

Inferred From

FANCC [nucleoplasm] (Homo sapiens)

Cross References

PRO

O35870

RGD

2593

Cite Us!