Reactome | DRD4 [plasma membrane]

DRD4 [plasma membrane]

Stable Identifier

R-RNO-390809

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P30729

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        DRD3,4:DA [plasma membrane] (Rattus norvegicus)
        
        DRD3,4 [plasma membrane] (Rattus norvegicus)
        
        DRD4 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        DRD3,4:DA [plasma membrane] (Rattus norvegicus)
        
        DRD3,4 [plasma membrane] (Rattus norvegicus)
        
        DRD4 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Amine ligand-binding receptors (Rattus norvegicus)
        
        Dopamine receptors (Rattus norvegicus)
        
        D2D3,4 bind to DA (Rattus norvegicus)
        
        DRD3,4 [plasma membrane] (Rattus norvegicus)
        
        DRD4 [plasma membrane] (Rattus norvegicus)
        
        DRD3,4:DA [plasma membrane] (Rattus norvegicus)
        
        DRD3,4 [plasma membrane] (Rattus norvegicus)
        
        DRD4 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P30729

Reference Genes

ENSEMBL:ENSRNOG00000017927

UCSC:P30729

Participates

as a member of

DRD3,4 [plasma membrane] (Rattus norvegicus)

Inferred From

DRD4 [plasma membrane] (Homo sapiens)

Cross References

ZINC - Investigational

DRD4_RAT

ZINC - Metabolites

DRD4_RAT

ZINC - World Drugs

DRD4_RAT

ZINC - FDA approved

DRD4_RAT

ZINC - Substances

DRD4_RAT

ZINC - Biogenic

DRD4_RAT

ZINC target

P30729

PRO

P30729

GlyGen

P30729

RGD

2522

ZINC - Predictions - Purchasable

DRD4_RAT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18090	1	ADRB1 [plasma membrane] (R-RNO-390653)	0.471	2

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