Reactome | Tpm4 [cytosol]

Tpm4 [cytosol]

Stable Identifier

R-RNO-390548

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

TPM4, P09495

Locations in the PathwayBrowser

Expand all

Muscle contraction (Rattus norvegicus)

- Smooth Muscle Contraction (Rattus norvegicus)
  - Calcium Binds Caldesmon (Rattus norvegicus)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Rattus norvegicus)
      - Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
  - Myosin Binds ATP (Rattus norvegicus)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
  - Release Of ADP From Myosin (Rattus norvegicus)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
- Striated Muscle Contraction (Rattus norvegicus)
  - ATP Hydrolysis By Myosin (Rattus norvegicus)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
  - Calcium Binds Troponin-C (Rattus norvegicus)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - Inactive Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
  - Myosin Binds ATP (Rattus norvegicus)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
  - Release Of ADP From Myosin (Rattus norvegicus)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Rattus norvegicus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Rattus norvegicus)
        
        Tropomyosin [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase cycle (Rattus norvegicus)
      - RHOV GTPase cycle (Rattus norvegicus)
        
        RHOV binds effectors at the plasma membrane (Rattus norvegicus)
        
        RHOV effectors [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Rattus norvegicus)
        
        RHOV effectors [cytosol] (Rattus norvegicus)
        
        Tpm4 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P09495

Gene Names

Tpm4

Reference Genes

BioGPS Gene:24852 Tpm4

ENSEMBL:ENSRNOG00000015496

ENSEMBL:ENSRNOG00055010361

ENSEMBL:ENSRNOG00060010959

ENSEMBL:ENSRNOG00065021866

KEGG:rno:24852 Tpm4

Monarch:24852 Tpm4

NCBI Gene:24852 Tpm4

UCSC:P09495 Tpm4

Reference Transcript

RefSeq:NM_012678.2 Tpm4

Other Identifiers

10790712

1368838_at

1371653_at

17710651

24852

5641041

5681796

5683798

5826852

6094328

6195980

6229555

6253209

6516514

6537589

A_43_P11514

GE19897

GO:0002102

GO:0003779

GO:0005737

GO:0005856

GO:0008092

GO:0030154

GO:0030220

GO:0030863

GO:0043226

GO:0051015

ILMN_1357093

J02780_at

PH_rn_0002731

rc_AI230284_at

Participates

as a candidate of

RHOV effectors [cytosol] (Rattus norvegicus)

as a member of

Tropomyosin [cytosol] (Rattus norvegicus)

Inferred From

TPM4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_036810.1

ENSEMBL

ENSRNOP00000072238, ENSRNOT00000089056, ENSRNOG00000015496

PRO

P09495

RGD

3899