Reactome | ADCY2 [plasma membrane]

ADCY2 [plasma membrane]

Stable Identifier

R-RNO-379052

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P26769

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - GABA receptor activation (Rattus norvegicus)
      - GABA B receptor activation (Rattus norvegicus)
        
        Activation of GABAB receptors (Rattus norvegicus)
        
        Adenylate cyclase inhibitory pathway (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - DAG and IP3 signaling (Rattus norvegicus)
    - CaM pathway (Rattus norvegicus)
      - Calmodulin induced events (Rattus norvegicus)
        
        PKA-mediated phosphorylation of CREB (Rattus norvegicus)
        
        PKA activation (Rattus norvegicus)
        
        Adenylate cyclase produces cAMP (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Opioid Signalling (Rattus norvegicus)
        
        G-protein mediated events (Rattus norvegicus)
        
        Adenylate cyclase activating pathway (Rattus norvegicus)
        
        Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase inhibitory pathway (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        PLC beta mediated events (Rattus norvegicus)
        
        Ca-dependent events (Rattus norvegicus)
        
        CaM pathway (Rattus norvegicus)
        
        Calmodulin induced events (Rattus norvegicus)
        
        PKA-mediated phosphorylation of CREB (Rattus norvegicus)
        
        PKA activation (Rattus norvegicus)
        
        Adenylate cyclase produces cAMP (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
    - G alpha (z) signalling events (Rattus norvegicus)
      - G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Rattus norvegicus)
        
        Adenylate cyclase [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)
- Signaling by Hedgehog (Rattus norvegicus)
  - Hedgehog 'off' state (Rattus norvegicus)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)
      - adenylate cyclases:Mg2+ [plasma membrane] (Rattus norvegicus)
        
        adenylate cyclases [plasma membrane] (Rattus norvegicus)
        
        ADCY2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P26769

Reference Genes

BioGPS Gene:81636

ENSEMBL:ENSRNOG00000032150

KEGG Gene (Rattus norvegicus):81636

Monarch:81636

NCBI Gene:81636

UCSC:P26769

Reference Transcript

RefSeq:NM_031007.1

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Rattus norvegicus)

as a member of

Adenylate cyclase [plasma membrane] (Rattus norvegicus)

Inferred From

ADCY2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_112269.1

ZINC - Investigational

ADCY2_RAT

ZINC - Metabolites

ADCY2_RAT

IntEnz

4.6.1.1

ZINC - Substances

ADCY2_RAT

ZINC - Biogenic

ADCY2_RAT

ZINC target

P26769

PRO

P26769

RGD

619965

ZINC - Predictions - Purchasable

ADCY2_RAT

PDB

1CUL, 1AZS, 3C16, 3G82, 1TL7, 1CJT, 1CJK, 3C15, 2GVD, 1AB8, 3MAA, 1CJU, 1CS4, 3C14, 1U0H, 2GVZ, 1CJV

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