Reactome | Cenpu [cytosol]

Cenpu [cytosol]

Stable Identifier

R-RNO-375315

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

MLF1IP, Q4V8G7

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate Formins (Rattus norvegicus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-O complex [cytosol] (Rattus norvegicus)
        
        Cenpu [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q4V8G7

Gene Names

Cenpu

Reference Genes

BioGPS Gene:306464 Cenpu

ENSEMBL:ENSRNOG00000022261

ENSEMBL:ENSRNOG00055011439

KEGG:rno:306464 Cenpu

Monarch:306464 Cenpu

NCBI Gene:306464 Cenpu

UCSC:Q4V8G7 Cenpu

Reference Transcript

RefSeq:NM_001025673.1 Cenpu

Other Identifiers

10791661

1393844_at

17711701

306464

5638742

5694130

5770451

5811612

5842286

5858674

5876110

5877097

5934707

6163791

6423592

6554774

6619760

6721487

A_43_P18241

A_44_P372810

GE1186647

PH_rn_0002817

Participates

as a component of

CENP-O complex [cytosol] (Rattus norvegicus)

Other forms of this molecule

Cenpu [nucleoplasm]

Inferred From

MLF1IP [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020844.1

ENSEMBL

ENSRNOG00000022261, ENSRNOP00000046417, ENSRNOT00000041596

PRO

Q4V8G7

RGD

1562566

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