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Vcl [cytosol]
Stable Identifier
R-RNO-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
VCL, P85972
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Rattus norvegicus)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Rattus norvegicus)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
Release of platelet cytosolic components (Rattus norvegicus)
Platelet releasate cytosolic proteins [cytosol] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Muscle contraction (Rattus norvegicus)
Smooth Muscle Contraction (Rattus norvegicus)
Calcium Binds Caldesmon (Rattus norvegicus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Rattus norvegicus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Myosin Binds ATP (Rattus norvegicus)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Release Of ADP From Myosin (Rattus norvegicus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
Vcl [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P85972
Gene Names
Vcl
Reference Genes
BioGPS Gene:305679 Vcl
ENSEMBL:ENSRNOG00000010765
ENSEMBL:ENSRNOG00055019101
ENSEMBL:ENSRNOG00060012368
ENSEMBL:ENSRNOG00065010245
KEGG:rno:305679 Vcl
Monarch:305679 Vcl
NCBI Gene:305679 Vcl
UCSC:P85972 Vcl
Reference Transcript
RefSeq:NM_001107248.1 Vcl
Other Identifiers
10782247
1372905_at
1398476_at
17700958
305679
5632276
5672878
5697152
5701685
5702190
5760786
5785094
5841484
5880899
6047761
6178330
6200218
6237861
6242791
6273710
6291460
6323545
6376009
6407135
6426766
6458881
6499302
6544790
6569537
6569797
6610497
6681930
6722047
6722277
6725921
A_42_P811423
A_44_P471691
GE1301866
GE19268
GO:0002009
GO:0002102
GO:0002162
GO:0003779
GO:0005198
GO:0005737
GO:0005856
GO:0005886
GO:0005903
GO:0005911
GO:0005912
GO:0005915
GO:0005916
GO:0005925
GO:0007155
GO:0008092
GO:0015629
GO:0016020
GO:0030032
GO:0030154
GO:0030334
GO:0031625
GO:0032991
GO:0034330
GO:0034333
GO:0034394
GO:0042383
GO:0043034
GO:0043226
GO:0043297
GO:0044291
GO:0045294
GO:0048675
GO:0048856
GO:0048870
GO:0051015
GO:0051893
GO:0061826
GO:0070161
GO:0090136
GO:0090636
GO:0090637
GO:1903140
GO:1904702
GO:1990357
PH_rn_0013684
rc_AI136460_at
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Rattus norvegicus)
as an input of
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Rattus norvegicus)
Other forms of this molecule
Vcl [cytosol]
Vcl [ficolin-1-rich granule lumen]
Vcl [secretory granule lumen]
Vcl [extracellular region]
Vcl [specific granule lumen]
Inferred From
VCL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001100718.1
ENSEMBL
ENSRNOP00000015179
,
ENSRNOT00000015179
PRO
P85972
RGD
1311217
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