Reactome | Vcl [cytosol]

Vcl [cytosol]

Stable Identifier

R-RNO-350753

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

VCL, P85972

Locations in the PathwayBrowser

Expand all

Hemostasis (Rattus norvegicus)

- Platelet activation, signaling and aggregation (Rattus norvegicus)
  - Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
    - Platelet degranulation (Rattus norvegicus)
      - Release of platelet cytosolic components (Rattus norvegicus)
        
        Platelet releasate cytosolic proteins [cytosol] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)

Muscle contraction (Rattus norvegicus)

- Smooth Muscle Contraction (Rattus norvegicus)
  - Calcium Binds Caldesmon (Rattus norvegicus)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Rattus norvegicus)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
  - Myosin Binds ATP (Rattus norvegicus)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
  - Release Of ADP From Myosin (Rattus norvegicus)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Rattus norvegicus)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        Dissociation of RAS:RAF complex (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        RAF phosphorylates MAP2K dimer (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
        
        Vinculin bound to PIP2 [plasma membrane] (Rattus norvegicus)
        
        Vcl [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P85972

Gene Names

Vcl

Reference Genes

BioGPS Gene:305679 Vcl

ENSEMBL:ENSRNOG00000010765

ENSEMBL:ENSRNOG00055019101

ENSEMBL:ENSRNOG00060012368

ENSEMBL:ENSRNOG00065010245

KEGG:rno:305679 Vcl

Monarch:305679 Vcl

NCBI Gene:305679 Vcl

UCSC:P85972 Vcl

Reference Transcript

RefSeq:NM_001107248.2 Vcl

Other Identifiers

10782247

1372905_at

1398476_at

17700958

305679

5632276

5672878

5697152

5701685

5702190

5760786

5785094

5841484

5880899

6047761

6178330

6200218

6237861

6242791

6273710

6291460

6323545

6376009

6407135

6426766

6458881

6499302

6544790

6569537

6569797

6610497

6681930

6722047

6722277

6725921

A_42_P811423

A_44_P471691

GE1301866

GE19268

GO:0001725

GO:0002009

GO:0002102

GO:0002162

GO:0003779

GO:0005198

GO:0005737

GO:0005856

GO:0005884

GO:0005886

GO:0005903

GO:0005911

GO:0005912

GO:0005915

GO:0005916

GO:0005925

GO:0007155

GO:0008013

GO:0008092

GO:0014704

GO:0015629

GO:0016020

GO:0030016

GO:0030018

GO:0030032

GO:0030334

GO:0031267

GO:0031625

GO:0032991

GO:0034330

GO:0034333

GO:0034394

GO:0042383

GO:0042995

GO:0043034

GO:0043226

GO:0043297

GO:0044291

GO:0045294

GO:0048471

GO:0048675

GO:0051015

GO:0051893

GO:0061826

GO:0070161

GO:0090136

GO:0090636

GO:0090637

GO:1903140

GO:1904702

GO:1990357

PH_rn_0013684

rc_AI136460_at

Participates

as a component of

as a member of

Platelet releasate cytosolic proteins [cytosol] (Rattus norvegicus)

as an input of

Other forms of this molecule

Vcl [cytosol]

Vcl [secretory granule lumen]

Vcl [specific granule lumen]

Vcl [extracellular region]

Vcl [ficolin-1-rich granule lumen]

Inferred From

VCL [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOP00000015179, ENSRNOG00000010765, ENSRNOT00000015179

PRO

P85972

RGD

1311217

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