Reactome | Lmnb1 [nucleoplasm]

Lmnb1 [nucleoplasm]

Stable Identifier

R-RNO-264867

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

LMNB1, P70615

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Nuclear Envelope (NE) Reassembly (Rattus norvegicus)
        
        Initiation of Nuclear Envelope (NE) Reformation (Rattus norvegicus)
        
        BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Rattus norvegicus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Rattus norvegicus)
        
        Lamin filaments [nucleoplasm] (Rattus norvegicus)
        
        Lamin dimers [nucleoplasm] (Rattus norvegicus)
        
        Lamin B1 dimer [nucleoplasm] (Rattus norvegicus)
        
        Lmnb1 [nucleoplasm] (Rattus norvegicus)
    - Mitotic Prophase (Rattus norvegicus)
      - Nuclear Envelope Breakdown (Rattus norvegicus)
        
        Depolymerization of the Nuclear Lamina (Rattus norvegicus)
        
        Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Rattus norvegicus)
        
        Lamin filaments [nucleoplasm] (Rattus norvegicus)
        
        Lamin dimers [nucleoplasm] (Rattus norvegicus)
        
        Lamin B1 dimer [nucleoplasm] (Rattus norvegicus)
        
        Lmnb1 [nucleoplasm] (Rattus norvegicus)
        
        VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Rattus norvegicus)
        
        Lamin filaments [nucleoplasm] (Rattus norvegicus)
        
        Lamin dimers [nucleoplasm] (Rattus norvegicus)
        
        Lamin B1 dimer [nucleoplasm] (Rattus norvegicus)
        
        Lmnb1 [nucleoplasm] (Rattus norvegicus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Rattus norvegicus)
        
        Lamin filaments [nucleoplasm] (Rattus norvegicus)
        
        Lamin dimers [nucleoplasm] (Rattus norvegicus)
        
        Lamin B1 dimer [nucleoplasm] (Rattus norvegicus)
        
        Lmnb1 [nucleoplasm] (Rattus norvegicus)

Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular Senescence (Rattus norvegicus)
    - DNA Damage/Telomere Stress Induced Senescence (Rattus norvegicus)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Rattus norvegicus)
        
        SAHF formation (Rattus norvegicus)
        
        Lmnb1 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P70615

Gene Names

Lmnb1

Reference Genes

BioGPS Gene:116685 Lmnb1

ENSEMBL:ENSRNOG00000013774

KEGG:rno:116685 Lmnb1

Monarch:116685 Lmnb1

NCBI Gene:116685 Lmnb1

UCSC:P70615 Lmnb1

Reference Transcript

RefSeq:NM_053905.2 Lmnb1

Participates

as a component of

Lamin B1 dimer [nucleoplasm] (Rattus norvegicus)

as an input of

Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)

This entity regulates

Negatively

SAHF formation (Rattus norvegicus)

Other forms of this molecule

phospho-Lmnb1 [nucleoplasm]

Lmnb1 [cytosol]

Lmnb1 [nuclear envelope]

Inferred From

LMNB1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_446357.2

PRO

P70615

RGD

620522