Reactome | HBB [extracellular region]

HBB [extracellular region]

Stable Identifier

R-RNO-2168872

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

P02091

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Binding and Uptake of Ligands by Scavenger Receptors (Rattus norvegicus)
  - Scavenging of heme from plasma (Rattus norvegicus)
    - Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)
      - ApoHb [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
      - MetHb [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferriheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
    - Haptoglobin binds Hemoglobin (Rattus norvegicus)
      - Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
      - Hemoglobin:Haptoglobin [extracellular region] (Rattus norvegicus)
        
        Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
    - Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)
      - Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
      - Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Rattus norvegicus)
        
        Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
    - Haptoglobin:Hemoglobin binds CD163 (Rattus norvegicus)
      - Hemoglobin:Haptoglobin [extracellular region] (Rattus norvegicus)
        
        Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
      - Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Rattus norvegicus)
        
        Hemoglobin:Haptoglobin [extracellular region] (Rattus norvegicus)
        
        Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
    - Hemoglobin:Haptoglobin:CD163 is endocytosed (Rattus norvegicus)
      - Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Rattus norvegicus)
        
        Hemoglobin:Haptoglobin [extracellular region] (Rattus norvegicus)
        
        Hemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Deoxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)
        
        Oxyhemoglobin Dimer [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Rattus norvegicus)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Rattus norvegicus)
        
        HBB [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P02091

Reference Genes

BioGPS Gene:24440

ENSEMBL:ENSRNOG00000047098

ENSEMBL:ENSRNOG00000058105

ENSEMBL:ENSRNOG00000081310

KEGG:rno:24440

Monarch:24440

NCBI Gene:24440

UCSC:P02091

Reference Transcript

RefSeq:NM_033234.1

Participates

as a component of

as a member of

Other forms of this molecule

CO-H+-HBB [cytosol]

HBB [endocytic vesicle lumen]

HBB [ficolin-1-rich granule lumen]

HBB [tertiary granule lumen]

HBB [cytosol]

Inferred From

HBB [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_150237.1

PRO

P02091

GlyGen

P02091

RGD

2783

PDB

3DHT, 3HF4

Cite Us!