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Glycogen synthase kinase-3 beta [cytosol]
Stable Identifier
R-RNO-198619
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
KG3B_RAT, Gsk3b
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
Constitutive phosphorylation by GSK3 (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
Semaphorin interactions (Rattus norvegicus)
CRMPs in Sema3A signaling (Rattus norvegicus)
Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog 'off' state (Rattus norvegicus)
GLI3 is processed to GLI3R by the proteasome (Rattus norvegicus)
GSK3 phosphorylates p-GLI3 (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
AXIN is phosphorylated in the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Assembly of the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Association of beta-catenin with the destruction complex (Rattus norvegicus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Beta-catenin phosphorylation cascade (Rattus norvegicus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of APC component of the destruction complex (Rattus norvegicus)
CK1alpha (GSK3) [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Rattus norvegicus)
Beta-catenin is released from the destruction complex (Rattus norvegicus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
FRAT proteins bind GSK3beta (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Glycogen synthase kinase-3 beta [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P18266 Gsk3b
Gene Names
Gsk3b
Chain
chain:1-420
Reference Genes
BioGPS Gene:84027 Gsk3b
KEGG:rno:84027 Gsk3b
Monarch:84027 Gsk3b
NCBI Gene:84027 Gsk3b
UCSC:P18266 Gsk3b
Reference Transcript
RefSeq:NM_032080.1 Gsk3b
Participates
as a component of
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
FRAT1,2:GSK3beta [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
as an input of
Assembly of the destruction complex (Rattus norvegicus)
FRAT proteins bind GSK3beta (Rattus norvegicus)
as a candidate of
CK1alpha (GSK3) [cytosol] (Rattus norvegicus)
as a member of
GSK3 [cytosol] (Rattus norvegicus)
Other forms of this molecule
GSK3B [nucleoplasm]
Phospho-GSK3b [cytosol]
Inferred From
GSK3B [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_114469.1
ZINC - Substances
GSK3B_RAT
ZINC target
P18266
PRO
P18266
RGD
70982
ZINC - Predictions - Purchasable
GSK3B_RAT
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