Reactome | RT1-Da [plasma membrane]

RT1-Da [plasma membrane]

Stable Identifier

R-RNO-197588

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

HLA class II histocompatibility antigen, DR alpha chain precursor, Q6MG98

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - MHC class II antigen presentation (Rattus norvegicus)
    - Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)
      - MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - LAG3 (CD233) binds MHC II (Rattus norvegicus)
      - LAG3:MHC II [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)
      - MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
  - Regulation of T cell activation by CD28 family (Rattus norvegicus)
    - Co-inhibition by PD-1 (Rattus norvegicus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
  - TCR signaling (Rattus norvegicus)
    - Downstream TCR signaling (Rattus norvegicus)
      - Change of PKC theta conformation (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - Generation of second messenger molecules (Rattus norvegicus)
      - Phosphorylation of PLC-gamma1 (Rattus norvegicus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of SLP-76 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of TBSMs in LAT (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
      - Activation of Lck (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Inactivation of LCK by PTPN22 (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Inactivation of Lck by Csk (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
    - Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
      - Activation of ZAP-70 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
        
        HLA II alpha chain [plasma membrane] (Rattus norvegicus)
        
        RT1-Da [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6MG98

Gene Names

RT1-Da

Reference Genes

BioGPS Gene:294269 RT1-Da

CTD Gene:294269 RT1-Da

ENSEMBL:ENSRNOG00000032844

KEGG:rno:294269 RT1-Da

Monarch:294269 RT1-Da

NCBI Gene:294269 RT1-Da

UCSC:Q6MG98 RT1-Da

Reference Transcript

Other Identifiers

10828344

1370883_at

17753138

294269

5656627

5916222

5929473

6028768

6206316

6265065

6369474

6370498

A_44_P367688

A_44_P991532

GE21186

GO:0001772

GO:0001916

GO:0002376

GO:0002469

GO:0002491

GO:0002503

GO:0002504

GO:0005764

GO:0005765

GO:0005886

GO:0006955

GO:0009986

GO:0016020

GO:0019882

GO:0019886

GO:0030247

GO:0031902

GO:0032831

GO:0042605

GO:0042608

GO:0042613

GO:0043382

GO:0045622

GO:0050877

GO:0050890

GO:2000516

ILMN_1376935

M15562_g_at

PH_rn_0014526

Participates

as a member of

HLA II alpha chain [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

RT1-Da [lumenal side of endoplasmic reticulum membrane]

RT1-Da [ER to Golgi transport vesicle membrane]

RT1-Da [Golgi membrane]

RT1-Da [trans-Golgi network membrane]

RT1-Da [transport vesicle membrane]

RT1-Da [clathrin-coated endocytic vesicle membrane]

RT1-Da [endocytic vesicle membrane]

RT1-Da [lysosomal membrane]

Inferred From

HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_038954421.1, NP_001008847.1

ENSEMBL

ENSRNOT00000048332, ENSRNOP00000048774, ENSRNOG00000032844

RGD

1593283

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