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beta-NGF homodimer [extracellular region]
Stable Identifier
R-RNO-193861
Type
Complex
Species
Rattus norvegicus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NADE modulates death signalling (Rattus norvegicus)
14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p75NTR binds to NADE (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NRIF signals cell death from the nucleus (Rattus norvegicus)
TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NFG and proNGF binds to p75NTR (Rattus norvegicus)
NGF homodimer binds to p75NTR (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p75NTR regulates axonogenesis (Rattus norvegicus)
Axonal growth stimulation (Rattus norvegicus)
NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
MYD88 dissociates (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
TRAF6 is auto-ubiquitinated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p62 recruits an atypical PKC (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
p75NTR interacts with RIP2 (Rattus norvegicus)
NGF:p75NTR:RIP2 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Expression and Processing of Neurotrophins (Rattus norvegicus)
NGF processing (Rattus norvegicus)
Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Activation of TRKA receptors (Rattus norvegicus)
TRKA activation by NGF (Rattus norvegicus)
Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
The bound receptor dimerizes (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Retrograde neurotrophin signalling (Rattus norvegicus)
Axonal transport of NGF:Trk complexes (Rattus norvegicus)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
ARMS-mediated activation (Rattus norvegicus)
ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Crk's SH3 domain engages C3G (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
beta-NGF homodimer [extracellular region] (Rattus norvegicus)
Participants
components
x 2
beta-NGF [extracellular region]
(Rattus norvegicus)
Participates
as a component of
Beta-NGF homodimer:p75NTR dimer [plasma membrane] (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor complex [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
as an input of
NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)
NGF homodimer binds to p75NTR (Rattus norvegicus)
beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)
as a member of
NGF ligand homodimer [extracellular region] (Rattus norvegicus)
as an output of
Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)
Inferred From
mature beta-NGF homodimer [extracellular region]
(Homo sapiens)
beta-NGF homodimer [extracellular region]
(Homo sapiens)
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