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About
What is Reactome ?
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Klotho bound to FGF23 [plasma membrane]
Stable Identifier
R-RNO-190208
Type
Complex
Species
Rattus norvegicus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:FLRT [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
FRS-mediated FGFR1 signaling (Rattus norvegicus)
Activated FGFR1 binds FRS2 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 binds FRS3 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 phosphorylates FRS3 (Rattus norvegicus)
Activated FGFR1:FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
PI-3K cascade:FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Phospholipase C-mediated cascade: FGFR1 (Rattus norvegicus)
Activated FGFR1 binds PLCG1 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
SHC-mediated cascade:FGFR1 (Rattus norvegicus)
Activated FGFR1 binds SHC1 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)
Activated FGFR1:SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
FGFR1 ligand binding and activation (Rattus norvegicus)
FGFR1c and Klotho ligand binding and activation (Rattus norvegicus)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Fgf23 [extracellular region]
(Rattus norvegicus)
Klotho homodimer [plasma membrane]
(Rattus norvegicus)
Participates
as an input of
FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)
as a component of
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Inferred From
Klotho bound to FGF23 [plasma membrane]
(Homo sapiens)
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