Reactome | Ap2s1 [cytosol]

Ap2s1 [cytosol]

Stable Identifier

R-RNO-182197

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

AP2S1, P62744

Locations in the PathwayBrowser

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Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - AP-2 directly binds some endocytic cargo (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        AP2:chlorpromazine [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - AP2 binds chlorpromazine (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        AP2:chlorpromazine [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)
      - AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - Recruitment of AP-2 complex and clathrin (Rattus norvegicus)
      - AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Ap2s1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P62744 Ap2s1

Gene Names

Ap2s1, Ap17, Claps2

Chain

chain:1-142

Reference Genes

BioGPS Gene:65046 Ap2s1

KEGG:rno:65046 Ap2s1

Monarch:65046 Ap2s1

NCBI Gene:65046 Ap2s1

UCSC:P62744 Ap2s1

Reference Transcript

RefSeq:NM_022952.2 Ap2s1

Other Identifiers

10704499

1386877_at

17613670

5658862

5865204

6028812

6059106

6092521

6405991

65046

6525009

A_64_P054506

GE1103305

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0008021

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030122

GO:0031410

GO:0035615

GO:0045202

GO:0048488

GO:0060090

GO:0072583

GO:0098794

GO:0098884

GO:0098894

GO:0098978

ILMN_1351091

PH_rn_0011679

U75917_at

U75917_g_at

Participates

as a component of

Other forms of this molecule

Ap2s1 [endolysosome membrane]

Ap2s1 [endocytic vesicle membrane]

Adaptor Protein 2 sigma 1 subunit [plasma membrane]

Ap2s1 [plasma membrane]

Ap2s1 [clathrin-coated endocytic vesicle membrane]

Inferred From

AP2S1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_075241.2

ZINC - World Drugs

AP2S1_RAT

ENSEMBL

ENSRNOG00000015865, ENSRNOP00000083093, ENSRNOT00000119694

ZINC - FDA approved

AP2S1_RAT

ZINC - Substances

AP2S1_RAT

ZINC target

P62744

PRO

P62744

RGD

620188

ZINC - Predictions - Purchasable

AP2S1_RAT

PDB

4NEE, 6OWO, 6OXL, 6OWT

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