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phospho-Tbk1 [cytosol]
Stable Identifier
R-RNO-168379
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
p-S172-TBK1, D4A7D3
Locations in the PathwayBrowser
Expand all
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
Selective autophagy (Rattus norvegicus)
Mitophagy (Rattus norvegicus)
PINK1-PRKN Mediated Mitophagy (Rattus norvegicus)
MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria (Rattus norvegicus)
MAP1LC3B:p-S-TBK1:p-S-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
OPTN binds ATG9A (Rattus norvegicus)
ATG9A:p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Rattus norvegicus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
p-S-TBK1 phosphorylates OPTN (Rattus norvegicus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Cytosolic sensors of pathogen-associated DNA (Rattus norvegicus)
Regulation of innate immune responses to cytosolic DNA (Rattus norvegicus)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Rattus norvegicus)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
STING mediated induction of host immune responses (Rattus norvegicus)
IRF3-mediated induction of type I IFN (Rattus norvegicus)
IRF3 is phosphorylated by TBK1 (Rattus norvegicus)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
STAT6-mediated induction of chemokines (Rattus norvegicus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Rattus norvegicus)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Rattus norvegicus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TBK1 is phosphorylated within the activated TLR4 complex (Rattus norvegicus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D4A7D3
Gene Names
Tbk1
Reference Genes
BioGPS Gene:299827 Tbk1
ENSEMBL:ENSRNOG00000005528
KEGG:rno:299827 Tbk1
Monarch:299827 Tbk1
NCBI Gene:299827 Tbk1
UCSC:D4A7D3 Tbk1
Reference Transcript
RefSeq:NM_001106786.1 Tbk1
Other Identifiers
10902714
1376880_at
17836200
299827
5716617
5802351
5832698
5844592
5995442
6047959
6056800
6080854
6117626
6157705
6219230
6237802
6266041
6273707
6312672
6344726
6365872
6551324
6570155
6612940
6691079
6727623
6730802
6736605
A_43_P17992
A_44_P424541
GE1186914
GE1231450
GO:0002181
GO:0002218
GO:0002376
GO:0002753
GO:0003676
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0009299
GO:0010468
GO:0010508
GO:0010629
GO:0016071
GO:0016239
GO:0016740
GO:0019903
GO:0030154
GO:0031669
GO:0032479
GO:0032481
GO:0032727
GO:0032728
GO:0034142
GO:0038202
GO:0038203
GO:0042802
GO:0043123
GO:0043491
GO:0044565
GO:0045087
GO:0045944
GO:0045948
GO:0050830
GO:0051219
GO:0051897
GO:0060340
GO:0061470
GO:0061629
GO:0098542
GO:0106310
GO:0140096
GO:0140374
GO:0140896
GO:1904262
GO:1904263
GO:1904417
GO:1904515
ILMN_1367327
PH_rn_0007213
rc_AI639447_at
Participates
as a component of
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Rattus norvegicus)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Rattus norvegicus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Rattus norvegicus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-Tbk1 [cytosol]
phospho-Tbk1 [cytosol]
Tbk1 [cytosol]
Tbk1 [cytosol]
Inferred From
p-S172-TBK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 172 (in Homo sapiens)
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001100256.1
ENSEMBL
ENSRNOT00000009260
,
ENSRNOG00000005528
,
ENSRNOP00000009260
RGD
1588588
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