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Map3k14 [cytosol]
Stable Identifier
R-RNO-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
MAP3K14, D3ZTD1
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
p-S400-Cot phosphorylates NIK (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
TNFR2 non-canonical NF-kB pathway (Rattus norvegicus)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Rattus norvegicus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Rattus norvegicus)
K48polyUb-TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
NIK-->noncanonical NF-kB signaling (Rattus norvegicus)
Activation of NIK (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK phosphorylates IKKA dimer (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
NIK autophosphorylates on T559 (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Rattus norvegicus)
K48polyUb-TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TRAF3 binds BAFFR:BAFF (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TRAFs bind RANK:RANKL (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
Dectin-1 mediated noncanonical NF-kB signaling (Rattus norvegicus)
Activation of NIK (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK phosphorylates IKKA dimer (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Map3k14 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D3ZTD1
Gene Names
Map3k14
Reference Genes
BioGPS Gene:360640 Map3k14
ENSEMBL:ENSRNOG00000003278
ENSEMBL:ENSRNOG00000003278.7 Map3k14
KEGG Gene (Rattus norvegicus):360640 Map3k14
Monarch:360640 Map3k14
NCBI Gene:360640 Map3k14
UCSC:D3ZTD1 Map3k14
Reference Transcript
RefSeq:XM_017597407.1 Map3k14
RefSeq:NM_001108301.1 Map3k14
Other Identifiers
10748021
1391688_at
17662078
360640
5628472
5635753
5690396
5766625
5888968
5900830
5903098
5948683
5966661
5975556
6097844
6167760
6284325
6294672
6326282
6459274
6506525
6527231
6608126
6649725
A_44_P497290
A_44_P870046
A_64_P091618
GE1292470
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005829
GO:0006468
GO:0006955
GO:0007249
GO:0016740
GO:0023052
GO:0036211
GO:0038061
GO:0043226
GO:0043231
GO:0051607
GO:0071260
GO:0098542
GO:0140096
ILMN_1359019
PH_rn_0014981
Participates
as an input of
NIK autophosphorylates on T559 (Rattus norvegicus)
Active NIK phosphorylates IKKA dimer (Rattus norvegicus)
Activation of NIK (Rattus norvegicus)
p-S400-Cot phosphorylates NIK (Rattus norvegicus)
as an output of
Activation of NIK (Rattus norvegicus)
Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)
as a component of
K48polyUb-TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF3:NIK [cytosol] (Rattus norvegicus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-Map3k14 [cytosol]
Map3k14 [cytosol]
phospho-Map3k14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_017452896.1
,
NP_001101771.1
Ensembl
ENSRNOP00000004532
,
ENSRNOG00000003278
,
ENSRNOT00000004532
PRO
D3ZTD1
RGD
1310487
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