Reactome | Cyfip2 [cytosol]

Cyfip2 [cytosol]

Stable Identifier

R-RNO-1671642

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

CYFIP2, A0A0G2JT63

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
      - ABL phosphorylates WAVEs (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
      - Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
      - p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by VEGF (Rattus norvegicus)
    - VEGFA-VEGFR2 Pathway (Rattus norvegicus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        ABL phosphorylates WAVEs (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
    - RHO GTPase cycle (Rattus norvegicus)
      - RAC1 GTPase cycle (Rattus norvegicus)
        
        RAC1 binds effectors at the plasma membrane (Rattus norvegicus)
        
        RAC1 effectors [cytosol] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Rattus norvegicus)
        
        RAC1 effectors [cytosol] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)
        
        Cyfip2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JT63

Gene Names

Cyfip2

Reference Genes

ENSEMBL:ENSRNOG00000006557

UCSC:A0A0G2JT63 Cyfip2

Other Identifiers

10742254

1374939_at

1398533_at

17655666

303073

5683612

5715230

5749282

5750387

5786982

5859223

5901712

5903277

6003525

6044996

6047878

6190697

6209759

6211954

6216748

6225597

6230305

6246130

6248065

6274977

6296343

6312678

6341297

6354690

6386289

6394665

6452042

6457812

6471751

6579980

6631482

6655838

6660181

6673391

6692459

6693621

6700307

6732748

6737907

A_42_P773155

A_44_P380332

A_44_P625415

GE1150903

GE1286049

GO:0000902

GO:0005737

GO:0006915

GO:0007411

GO:0030031

GO:0030833

GO:0031175

GO:0031209

GO:0031267

GO:0043005

GO:0045202

GO:0045862

GO:0048471

GO:0051388

GO:0097484

GO:0098609

GO:0150052

ILMN_1372050

PH_rn_0009986

rc_AA893984_at

Participates

as a member of

CYFIP1,CYFIP2 [cytosol] (Rattus norvegicus)

Inferred From

CYFIP2 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOT00000081280, ENSRNOP00000068584, ENSRNOG00000006557

RGD

1305048

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