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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
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Traf6 [cytosol]
Stable Identifier
R-RNO-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
TRAF6, B5DF45
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Auto-ubiquitination of TRAF6 (Rattus norvegicus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p62:MEKK3 binds to TRAF6 (Rattus norvegicus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Alpha-protein kinase 1 signaling pathway (Rattus norvegicus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
K63polyUb-TRAF6 ubiquitinates TAK1 (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MALT1 oligomers (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 oligomer autoubiquitinates (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Rattus norvegicus)
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 oligomerizes (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Rattus norvegicus)
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated NF-kB activation (Rattus norvegicus)
Auto-ubiquitination of TRAF6 (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Rattus norvegicus)
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Oligomerization of TRAF6 (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Rattus norvegicus)
MALT1oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Rattus norvegicus)
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Rattus norvegicus)
MALT1oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Rattus norvegicus)
NOD1/2 Signaling Pathway (Rattus norvegicus)
RIP2 induces K63-linked ubiquitination of NEMO (Rattus norvegicus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
RIP2 is K63 polyubiquitinated (Rattus norvegicus)
RIP2 ubiquitin ligases [cytosol] (Rattus norvegicus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
IKK complex recruitment mediated by RIP1 (Rattus norvegicus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Rattus norvegicus)
RIP1 ubiqutin ligases [cytosol] (Rattus norvegicus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Rattus norvegicus)
Activated TLR4:TICAM1 recruits TRAF6 (Rattus norvegicus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Rattus norvegicus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ovarian tumor domain proteases (Rattus norvegicus)
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)
OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRIF signals cell death from the nucleus (Rattus norvegicus)
TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 polyubiquitinates NRIF (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Regulated proteolysis of p75NTR (Rattus norvegicus)
p75NTR ICD signals to NF-kB (Rattus norvegicus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
MYD88 dissociates (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 is auto-ubiquitinated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p62 recruits an atypical PKC (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B5DF45
Gene Names
Traf6
Reference Genes
BioGPS Gene:311245 Traf6
ENSEMBL:ENSRNOG00000004639
ENSEMBL:ENSRNOG00055000156
ENSEMBL:ENSRNOG00060002915
ENSEMBL:ENSRNOG00065016611
KEGG:rno:311245 Traf6
Monarch:311245 Traf6
NCBI Gene:311245 Traf6
UCSC:B5DF45 Traf6
Reference Transcript
RefSeq:XM_039104924.2 Traf6
RefSeq:NM_001107754.2 Traf6
Other Identifiers
10838100
1393809_at
17764266
311245
5636876
5654984
5949460
6004198
6058945
6181227
6446648
6486063
6486089
6514411
6546797
6569317
A_44_P433773
GE1157937
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0006955
GO:0006974
GO:0007165
GO:0007249
GO:0008270
GO:0009299
GO:0009887
GO:0009898
GO:0016071
GO:0016567
GO:0016740
GO:0019886
GO:0023035
GO:0030154
GO:0030316
GO:0030674
GO:0031624
GO:0031663
GO:0031666
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032991
GO:0033209
GO:0034142
GO:0034450
GO:0035631
GO:0038061
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042475
GO:0042742
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043124
GO:0043226
GO:0043422
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046330
GO:0046849
GO:0046872
GO:0048468
GO:0048471
GO:0048856
GO:0050852
GO:0051865
GO:0060090
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0070936
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0098696
GO:0098978
GO:0140096
GO:0140374
GO:0141124
GO:0141198
GO:1901701
GO:1904996
ILMN_1353721
PH_rn_0015605
Participates
as a component of
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Rattus norvegicus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
MALT1oligomer:TRAF6 [cytosol] (Rattus norvegicus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Rattus norvegicus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Rattus norvegicus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Rattus norvegicus)
as an input of
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)
Activated TLR4:TICAM1 recruits TRAF6 (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)
Oligomerization of TRAF6 (Rattus norvegicus)
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
TRAF6 binds MALT1 oligomers (Rattus norvegicus)
TRAF6 oligomerizes (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
p62:MEKK3 binds to TRAF6 (Rattus norvegicus)
IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)
p75NTR ICD signals to NF-kB (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Rattus norvegicus)
as a repeated unit of
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Other forms of this molecule
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [endosome membrane]
Traf6 [endosome membrane]
Traf6 [plasma membrane]
Traf6 [plasma membrane]
Traf6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001101224.1
,
XP_038960852.1
ENSEMBL
ENSRNOT00000006148
,
ENSRNOP00000006148
,
ENSRNOG00000004639
IntEnz
2.3.2.27
PRO
B5DF45
RGD
1306853
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