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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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Docs
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Traf6 [cytosol]
Stable Identifier
R-RNO-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
TRAF6, B5DF45
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p62:MEKK3 binds to TRAF6 (Rattus norvegicus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Alpha-protein kinase 1 signaling pathway (Rattus norvegicus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
TRAF6 binds MALT1 oligomers (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 oligomerizes (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Rattus norvegicus)
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated NF-kB activation (Rattus norvegicus)
Oligomerization of TRAF6 (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Rattus norvegicus)
MALT1oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Rattus norvegicus)
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
CBM oligomer:TRAF6 [plasma membrane] (Rattus norvegicus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Rattus norvegicus)
MALT1oligomer:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Rattus norvegicus)
Activated TLR4:TICAM1 recruits TRAF6 (Rattus norvegicus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Rattus norvegicus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ovarian tumor domain proteases (Rattus norvegicus)
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)
OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRIF signals cell death from the nucleus (Rattus norvegicus)
TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 polyubiquitinates NRIF (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
MYD88 dissociates (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
TRAF6 is auto-ubiquitinated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
p62 recruits an atypical PKC (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
Traf6 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B5DF45
Gene Names
Traf6
Reference Genes
BioGPS Gene:311245 Traf6
ENSEMBL:ENSRNOG00000004639
ENSEMBL:ENSRNOG00000004639.6 Traf6
ENSEMBL:ENSRNOG00055000156
ENSEMBL:ENSRNOG00060002915
ENSEMBL:ENSRNOG00065016611
KEGG Gene (Rattus norvegicus):311245 Traf6
Monarch:311245 Traf6
NCBI Gene:311245 Traf6
UCSC:B5DF45 Traf6
Reference Transcript
RefSeq:NM_001107754.2 Traf6
Other Identifiers
10838100
1393809_at
17764266
311245
5636876
5654984
5858435
5949460
6004198
6058945
6181227
6446648
6486063
6486089
6514411
6546797
6569317
A_44_P433773
GE1157937
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0007165
GO:0008270
GO:0012501
GO:0016567
GO:0016740
GO:0023052
GO:0036211
GO:0042981
GO:0043122
GO:0140096
ILMN_1353721
PH_rn_0015605
Participates
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Rattus norvegicus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
as a component of
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Rattus norvegicus)
hp-IRAK1:3xTRAF6 [cytosol] (Rattus norvegicus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Rattus norvegicus)
TRAF6 homotrimer [cytosol] (Rattus norvegicus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Rattus norvegicus)
MALT1oligomer:TRAF6 [cytosol] (Rattus norvegicus)
MEKK1:activated TRAF6 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Rattus norvegicus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
as an input of
IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
p62:MEKK3 binds to TRAF6 (Rattus norvegicus)
TRAF6 oligomerizes (Rattus norvegicus)
TRAF6 binds MALT1 oligomers (Rattus norvegicus)
Oligomerization of TRAF6 (Rattus norvegicus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)
TRAF6 binds MEKK1 (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
Activated TLR4:TICAM1 recruits TRAF6 (Rattus norvegicus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
as a repeated unit of
TRAF6 oligomer [cytosol] (Rattus norvegicus)
Other forms of this molecule
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [endosome membrane]
Traf6 [endosome membrane]
Traf6 [plasma membrane]
Traf6 [plasma membrane]
Traf6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001101224.1
Ensembl
ENSRNOG00000004639
,
ENSRNOT00000006148
,
ENSRNOP00000006148
PRO
B5DF45
RGD
1306853
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