Reactome | NDUFC1 [mitochondrial inner membrane]

NDUFC1 [mitochondrial inner membrane]

Stable Identifier

R-RNO-163940

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

mitochondrial inner membrane

Synonyms

D3ZS75

Locations in the PathwayBrowser

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Metabolism (Rattus norvegicus)

- Aerobic respiration and respiratory electron transport (Rattus norvegicus)
  - Respiratory electron transport (Rattus norvegicus)
    - Complex I biogenesis (Rattus norvegicus)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
      - ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Rattus norvegicus)
      - Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        NDUFC1 [mitochondrial inner membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZS75

Reference Genes

ENSEMBL:ENSRNOG00000038218

ENSEMBL:ENSRNOG00000070835

ENSEMBL:ENSRNOG00000089477

UCSC:D3ZS75

Other Identifiers

10823098

1392530_at

17747277

5749197

6195191

6337430

689938

A_64_P008077

GO:0005739

GO:0005743

GO:0045271

PH_rn_0022542

rc_AI104679_s_at

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)

Inferred From

NDUFC1 [mitochondrial inner membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOG00000089477, ENSRNOP00000106330, ENSRNOT00000163058

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