Tfam translocates from the cytosol to the mitochondrial matrix

Stable Identifier
R-RNO-1606727
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Tfam translocates from the cytosol to the mitochondrial matrix
Tfam is imported from the cytosol to the mitochondrial matrix. During importation the N-terminal transit peptide is cleaved.
Literature References
PubMed ID Title Journal Year
12930954 Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA

Garstka, HL, Schmitt, WE, Schultz, J, Sogl, B, Silakowski, B, Pérez-Martos, A, Montoya, J, Wiesner, RJ

Nucleic Acids Res 2003
11522837 Mechanism of mammalian mitochondrial DNA replication: import of mitochondrial transcription factor A into isolated mitochondria stimulates 7S DNA synthesis

Gensler, S, Weber, K, Schmitt, WE, Pérez-Martos, A, Enriquez, JA, Montoya, J, Wiesner, RJ

Nucleic Acids Res 2001
24058615 Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver

Picca, A, Pesce, V, Fracasso, F, Joseph, AM, Leeuwenburgh, C, Lezza, AM

PLoS ONE 2013
Participants
Input
Output
Orthologous Events
TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)
Authored
May, B  (2011-09-24)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-25)
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