Tyrosine phosphorylation of Prlr

Stable Identifier
R-RNO-1369121
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Tyrosine phosphorylation of Prlr
The model for Prl-induced Prlr activation suggests that Jak2 phosphorylates Prlr on specific tyrosine residues. Consistent with this, Jak2 and Prlr are phosphorylated in response to activating ligand (Lebrun et al. 1994) and PRLR tyrosine phosphorylation is required for subsequent Stat signaling (Pezet et al. 1997). Though this evidence is consistent with a role for JAK2, it has not been formally demonstrated that JAK2 is the kinase responsible for PRLR tyrosine phosphorylation.
Literature References
PubMed ID Title Journal Year
9312112 Tyrosine docking sites of the rat prolactin receptor required for association and activation of stat5

Ferrag, F, Edery, M, Kelly, PA, Pezet, A

J Biol Chem 1997
7537382 A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription

Goffin, V, Lebrun, JJ, Kelly, PA, Ullrich, A, Ali, S

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Orthologous Events
Tyrosine phosphorylation of PRLR (Homo sapiens)
Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-07-04)
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