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Hif1a [cytosol]
Stable Identifier
R-RNO-1234131
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
2xHP-HIF1A, O35800
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
26S proteasome degrades HIFalpha (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
Hif1a [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O35800
Gene Names
Hif1a
Reference Genes
BioGPS Gene:29560 Hif1a
ENSEMBL:ENSRNOG00000008292
KEGG Gene (Rattus norvegicus):29560 Hif1a
Monarch:29560 Hif1a
NCBI Gene:29560 Hif1a
UCSC:O35800 Hif1a
Reference Transcript
RefSeq:NM_024359.1 Hif1a
Participates
as a member of
hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
as an output of
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
Other forms of this molecule
Hif1a [cytosol]
Hif1a [nucleoplasm]
phospho-Hif1a [cytosol]
phospho-Hif1a [cytosol]
Hif1a [cytosol]
Hif1a [nucleoplasm]
Inferred From
2xHP-HIF1A [cytosol]
(Homo sapiens)
Modified Residues
Name
monohydroxylated proline at 402 (in Homo sapiens)
Coordinate
402
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 564 (in Homo sapiens)
Coordinate
564
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
RefSeq
NP_077335.1
PRO
O35800
RGD
61928
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