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Me2K5-HIST1H3A [nucleoplasm]
Stable Identifier
R-RNO-1214170
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Q6LED0
Locations in the PathwayBrowser
Expand all
Chromatin organization (Rattus norvegicus)
Chromatin modifying enzymes (Rattus norvegicus)
HDMs demethylate histones (Rattus norvegicus)
KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)
Me2K5-histone H3 [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)
Me2K5-histone H3 [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
KDM5A-D demethylate Me3K5-histone H3 (Rattus norvegicus)
Me2K5-histone H3 [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
PKMTs methylate histone lysines (Rattus norvegicus)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)
Me2K5-histone H3 [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)
Me2K5-histone H3 [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional regulation by RUNX1 (Rattus norvegicus)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Rattus norvegicus)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Estrogen-dependent gene expression (Rattus norvegicus)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Rattus norvegicus)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Rattus norvegicus)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm] (Rattus norvegicus)
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Me2K5-HIST1H3A [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q6LED0 Unknown
Chain
initiator methionine:1, chain:2-136
Reference Genes
BioGPS Gene:291159
BioGPS Gene:679994
BioGPS Gene:680498
CTD Gene:680498
KEGG:rno:291159
KEGG:rno:679994
KEGG:rno:680498
Monarch:291159
Monarch:679994
Monarch:680498
NCBI Gene:291159
NCBI Gene:679994
NCBI Gene:680498
UCSC:Q6LED0
Reference Transcript
RefSeq:NM_001408765.1
RefSeq:NM_001408762.1
RefSeq:NM_001013056.2
Other Identifiers
10795289
10798505
17719547
291159
5706659
5760418
5799006
5946906
6238457
680498
A_44_P744512
A_64_P048366
A_64_P068622
A_64_P128563
GO:0000786
GO:0003677
GO:0005198
GO:0030527
GO:0046982
rc_AI137974_f_at
Participates
as a candidate of
Me2K5-histone H3 [nucleoplasm] (Rattus norvegicus)
as a member of
Histone H3 (H3K4me2) [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
2xAcK-HIST1H3A [nucleoplasm]
Ack-Me3K5-HIST1H3A [nucleoplasm]
AcK-Me3K10-HIST1H3A [nucleoplasm]
AcK-Me3K28-HIST1H3A [nucleoplasm]
Me2aR27-HIST1H3A [nucleoplasm]
Me2aR18-HIST1H3A [nucleoplasm]
Me2sR9-HIST1H3A [nucleoplasm]
Me2sR3-HIST1H3A [nucleoplasm]
phospho-AcK9,14-p-S10-HIST1H3A [nucleoplasm]
phospho-AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
phospho-AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
phospho-AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
phospho-AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
phospho-AcK14,18-p-S10-HIST1H3A [nucleoplasm]
phospho-AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
phospho-AcK14,18-p-T11-HIST1H3A [nucleoplasm]
phospho-AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
Me2K28-HIST1H3A [nucleoplasm]
MeK37-HIST1H3A [nucleoplasm]
MeK80-HIST1H3A [nucleoplasm]
Me3K80-HIST1H3A [nucleoplasm]
Me2K80-HIST1H3A [nucleoplasm]
Me3K37-HIST1H3A [nucleoplasm]
Me2K37-HIST1H3A [nucleoplasm]
MeK10-HIST1H3A [nucleoplasm]
MeK28-HIST1H3A [nucleoplasm]
MeK-10-HIST1H3A [cytosol]
HIST1H3A [cytosol]
Me2aR3-HIST1H3A [nucleoplasm]
Me1K5-H3C1 [nucleoplasm]
histone H3.1 [nucleoplasm]
Me3K28-HIST1H3A [nucleoplasm]
Cit-R3,R9,R18,R27-HIST1H3A [extracellular region]
Me3K5-HIST1H3A [nucleoplasm]
Ack10-HIST1H3A [nucleoplasm]
Me2K10-HIST1H3A [nucleoplasm]
Ack15-HIST1H3A [nucleoplasm]
AcK24-HIST1H3A [nucleoplasm]
AcK5-HIST1H3A [nucleoplasm]
AcK19-HIST1H3A [nucleoplasm]
phospho-p-T12-HIST1H3A [nucleoplasm]
phospho-p-T12,MeK-10-HIST1H3A [nucleoplasm]
phospho-p-T12, Me2K-10-HIST1H3A [nucleoplasm]
phospho-p-T12, Me3K-10-HIST1H3A [nucleoplasm]
Me3K10-HIST1H3A [nucleoplasm]
Me2K5,Me2aR3-HIST1H3A [nucleoplasm]
MeR9-HIST1H3A [nucleoplasm]
MeR27-HIST1H3A [nucleoplasm]
MeR3-HIST1H3A [nucleoplasm]
MeR18-HIST1H3A [nucleoplasm]
Cit18-HIST1H3A [nucleoplasm]
Cit9-HIST1H3A [nucleoplasm]
Cit3-HIST1H3A [nucleoplasm]
Cit27-HIST1H3A [nucleoplasm]
Inferred From
Me2K5-HIST1H3A [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
N6,N6-dimethyl-L-lysine at 5 (in Homo sapiens)
Coordinate
5
PsiMod Name
N6,N6-dimethyl-L-lysine [MOD:00084]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.
Cross References
RefSeq
NP_001395694.1
,
NP_001013074.1
,
NP_001395691.1
ENSEMBL
ENSRNOT00000117255
,
ENSRNOT00000101837
,
ENSRNOP00000096532
,
ENSRNOP00000095460
,
ENSRNOG00000064755
,
ENSRNOP00000080297
,
ENSRNOP00000091493
,
ENSRNOG00000087873
,
ENSRNOT00000094137
,
ENSRNOG00000075562
,
ENSRNOT00000095973
,
ENSRNOG00000088564
PRO
Q6LED0
RGD
1311554
,
1598076
,
1591702
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